methyl 4-(6-chloro-5-(1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate

Base Information

Chemical Name:methyl 4-(6-chloro-5-(1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate
CAS No.:1187648-12-9
Molecular Formula:C₂₈H₂₁ClN₄O₄
Molecular Weight:512.952
Hs Code.:

Synonyms:methyl 4-(6-chloro-5-(1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate

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Chemical Property of methyl 4-(6-chloro-5-(1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate

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Technology Process of methyl 4-(6-chloro-5-(1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate

There total 2 articles about methyl 4-(6-chloro-5-(1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.6%

: 850567-96-3
(4-((methoxycarbonyl) amino)phenyl)boronic acid

: 1187648-11-8
2-(1-(3,6-dichloropyridazin-4-yl)-2-phenylethyl)isoindoline-1,3-dione

: 1187648-12-9
methyl 4-(6-chloro-5-(1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate

Guidance literature:: With potassium phosphate; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 5123-55-7
Nα-phthaloyl-L-phenylalanine

: 1187648-12-9
methyl 4-(6-chloro-5-(1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium peroxydisulfate; silver nitrate; trifluoroacetic acid / water / 0.83 h / 70 °C

2: potassium phosphate / triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

With ammonium peroxydisulfate; potassium phosphate; silver nitrate; trifluoroacetic acid; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; water; 2: Suzuki Coupling;

Reference yield:

: 1187648-12-9
methyl 4-(6-chloro-5-(1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate

: 76-05-1
trifluoroacetic acid

: methyl 4-(5-(1-amino-2-phenylethyl)-6-chloropyridazin-3-yl)phenylcarbamate trifluoroacetate

Guidance literature:: methyl 4-(6-chloro-5-(1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate; With hydrazine; In ethanol; at 80 ℃; for 4h;

trifluoroacetic acid; In methanol; water;