ethyl 2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)-3-nitrobenzoate

Base Information

• Chemical Name: ethyl 2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)-3-nitrobenzoate
• CAS No.: 1420880-44-9
• Molecular Formula: C₂₃H₁₉N₃O₄
• Molecular Weight: 405.39

Synonyms:ethyl 2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)-3-nitrobenzoate

Chemical Property of ethyl 2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)-3-nitrobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)-3-nitrobenzoate

There total 6 articles about ethyl 2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)-3-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.4%

ethyl 2-(tert-butoxycarbonyl((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[2H]-methyl))amino)-3-nitrobenzoate (1420880-43-8) → ethyl 2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[2H]-methyl)amino)-3-nitrobenzoate (1420880-44-9)

Guidance literature:

With hydrogenchloride; In methanol; ethyl acetate; at 20 ℃; for 2h;

DOI:10.1002/jlcr.2956

Reference yield:

2',3',5',6'-tetra-[2H]-4'-(bromomethyl)biphenyl-2-carbonitrile (1420880-42-7) → ethyl 2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[2H]-methyl)amino)-3-nitrobenzoate (1420880-44-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 7 h / Reflux

2: hydrogenchloride / methanol; ethyl acetate / 2 h / 20 °C

With hydrogenchloride; potassium carbonate; In methanol; ethyl acetate; acetonitrile;

DOI:10.1002/jlcr.2956

Reference yield:

2,3,5,6-tetra-[2H]-4-bromo toluene (112484-85-2) → ethyl 2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[2H]-methyl)amino)-3-nitrobenzoate (1420880-44-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: magnesium; iodine / tetrahydrofuran / 2.5 h / 20 - 50 °C

1.2: 8 h / 20 °C

2.1: trichlorophosphate; pyridine / 3 h / 105 °C / Cooling with ice

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 2 h / Reflux

4.1: potassium carbonate / acetonitrile / 7 h / Reflux

5.1: hydrogenchloride / methanol; ethyl acetate / 2 h / 20 °C

With pyridine; hydrogenchloride; N-Bromosuccinimide; iodine; potassium carbonate; magnesium; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; ethyl acetate; acetonitrile; 1.1: |Grignard Reaction;

DOI:10.1002/jlcr.2956

upstream raw materials:

2',3',5',6'-tetra-[²H]-4'-(bromomethyl)biphenyl-2-carbonitrile

ethyl 2-(tert-butoxycarbonyl((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))amino)-3-nitrobenzoate

2,3,5,6-tetra-[²H]-4-bromo toluene

2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

Downstream raw materials:

ethyl 3-amino-2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)benzoate

ethyl 1-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))-2-ethoxy-1H-benzo[d] imidazole-7-carboxylate

ethyl 1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))-2-ethoxy-1H-benzo [d]imidazole-7-carboxylate

C₂₄H₁₆⁽²⁾H₄N₆O₃

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1420880-44-9 ethyl 2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)-3-nitrobenzoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send