1-(2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-4'-C-hydroxymethyl-β-D-arabinofuranosyl)uracil

Base Information

Chemical Name:1-(2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-4'-C-hydroxymethyl-β-D-arabinofuranosyl)uracil
CAS No.:1240471-09-3
Molecular Formula:C₁₆H₂₇FN₂O₆Si
Molecular Weight:390.484
Hs Code.:

Synonyms:1-(2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-4'-C-hydroxymethyl-β-D-arabinofuranosyl)uracil

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Chemical Property of 1-(2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-4'-C-hydroxymethyl-β-D-arabinofuranosyl)uracil

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Technology Process of 1-(2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-4'-C-hydroxymethyl-β-D-arabinofuranosyl)uracil

There total 5 articles about 1-(2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-4'-C-hydroxymethyl-β-D-arabinofuranosyl)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: C₁₅H₂₃FN₂O₅Si

: 1240471-09-3,1445379-61-2
1-(2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-4'-C-hydroxymethyl-β-D-arabinofuranosyl)uracil

Guidance literature:: formaldehyd; C₁₅H₂₃FN₂O₅Si; With water; sodium hydroxide; In 1,4-dioxane; at 20 ℃;

With sodium tetrahydroborate; In 1,4-dioxane; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2010.06.025

Reference yield:

: C₁₆H₂₃FN₂O₆Si

: 1240471-09-3,1445379-61-2
1-(2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-4'-C-hydroxymethyl-β-D-arabinofuranosyl)uracil

Guidance literature:: With sodium tetrahydroborate; In 1,4-dioxane; ethanol; water; at 0 ℃; for 3h;
DOI:10.1016/j.bmcl.2010.05.090

Reference yield:

: 69123-94-0
1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)uracil

: 1240471-09-3,1445379-61-2
1-(2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-4'-C-hydroxymethyl-β-D-arabinofuranosyl)uracil

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 25 °C

2.1: acetic acid; water / tetrahydrofuran / 12 h / 80 °C

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 1 h / 80 °C

4.1: sodium hydroxide / water; 1,4-dioxane / 2 h / 25 °C

4.2: 1 h / 25 °C

With 1H-imidazole; water; acetic acid; sodium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;