Technology Process of N-(2-isopropoxy-5-(piperazin-1-yl)phenyl)pyrazine-2-carboxamide
There total 5 articles about N-(2-isopropoxy-5-(piperazin-1-yl)phenyl)pyrazine-2-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
methanol; water;
for 2h;
Inert atmosphere;
Reflux;
DOI:10.1016/j.bmcl.2014.03.073
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: pyridine / dichloromethane / 0.5 h / 0 °C / Molecular sieve
1.2: 16 h / 0 - 20 °C / Molecular sieve
2.1: 4-nitro-4-methyl-2,3,5,6-tetrabromo-2,5-cyclohexadien-1-one / tetrahydrofuran; diethyl ether / 5 h / 20 °C
3.1: hydrogen; palladium 10% on activated carbon; acetic acid / methanol / 24 h / 3102.97 Torr
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C / Molecular sieve; Inert atmosphere
4.2: 24 h / 20 °C / Inert atmosphere; Molecular sieve
5.1: potassium carbonate / methanol; water / 2 h / Inert atmosphere; Reflux
With
pyridine; palladium 10% on activated carbon; 4-nitro-4-methyl-2,3,5,6-tetrabromo-2,5-cyclohexadien-1-one; hydrogen; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.03.073
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 4-nitro-4-methyl-2,3,5,6-tetrabromo-2,5-cyclohexadien-1-one / tetrahydrofuran; diethyl ether / 5 h / 20 °C
2.1: hydrogen; palladium 10% on activated carbon; acetic acid / methanol / 24 h / 3102.97 Torr
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C / Molecular sieve; Inert atmosphere
3.2: 24 h / 20 °C / Inert atmosphere; Molecular sieve
4.1: potassium carbonate / methanol; water / 2 h / Inert atmosphere; Reflux
With
palladium 10% on activated carbon; 4-nitro-4-methyl-2,3,5,6-tetrabromo-2,5-cyclohexadien-1-one; hydrogen; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.03.073
