{4-[3,5-bis-(4-tert-butyl-benzyloxy)-benzyloxy]-6-hydroxymethyl-pyridin-2-yl}-methanol

Base Information

• Chemical Name: {4-[3,5-bis-(4-tert-butyl-benzyloxy)-benzyloxy]-6-hydroxymethyl-pyridin-2-yl}-methanol
• CAS No.: 852201-12-8
• Molecular Formula: C₃₆H₄₃NO₅
• Molecular Weight: 569.741

Synonyms:{4-[3,5-bis-(4-tert-butyl-benzyloxy)-benzyloxy]-6-hydroxymethyl-pyridin-2-yl}-methanol

Chemical Property of {4-[3,5-bis-(4-tert-butyl-benzyloxy)-benzyloxy]-6-hydroxymethyl-pyridin-2-yl}-methanol

Chemical Property:

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Technology Process of {4-[3,5-bis-(4-tert-butyl-benzyloxy)-benzyloxy]-6-hydroxymethyl-pyridin-2-yl}-methanol

There total 2 articles about {4-[3,5-bis-(4-tert-butyl-benzyloxy)-benzyloxy]-6-hydroxymethyl-pyridin-2-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-[3,5-bis-(4-tert-butyl-benzyloxy)-benzyloxy]-pyridine-2,6-dicarboxylic acid dimethyl ester (852201-11-7) → {4-[3,5-bis-(4-tert-butyl-benzyloxy)-benzyloxy]-6-hydroxymethyl-pyridin-2-yl}-methanol (852201-12-8)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 ℃; for 12h;

DOI:10.1021/ja0501363

Reference yield:

dimethyl 4-hydroxypyridine-2,6-dicarboxylate (19872-91-4) → {4-[3,5-bis-(4-tert-butyl-benzyloxy)-benzyloxy]-6-hydroxymethyl-pyridin-2-yl}-methanol (852201-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / Cs₂CO₃ / dimethylformamide / 2 h / 60 °C

2: 98 percent / NaBH₄ / methanol; tetrahydrofuran / 12 h / 0 °C

With sodium tetrahydroborate; caesium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/ja0501363

Reference yield: 40.0%

{4-[3,5-bis-(4-tert-butyl-benzyloxy)-benzyloxy]-6-hydroxymethyl-pyridin-2-yl}-methanol (852201-12-8) → 4-[3,5-bis-(4-tert-butyl-benzyloxy)-benzyloxy]-pyridine-2,6-dicarbaldehyde

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; at 100 ℃; for 12h;

DOI:10.1021/ja0501363

upstream raw materials:

4-[3,5-bis-(4-tert-butyl-benzyloxy)-benzyloxy]-pyridine-2,6-dicarboxylic acid dimethyl ester

dimethyl 4-hydroxypyridine-2,6-dicarboxylate

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