Dimethyl 4-hydroxypyridine-2,6-dicarboxylate

Base Information

• Chemical Name: Dimethyl 4-hydroxypyridine-2,6-dicarboxylate
• CAS No.: 19872-91-4
• Molecular Formula: C9H9NO5
• Molecular Weight: 211.174
• Hs Code.: 2933399090
• Mol file: 19872-91-4.mol

Synonyms:Pyridine-2,6-dicarboxylic acid, 1,4-dihydro-4-oxo-, dimethyl ester;

Chemical Property of Dimethyl 4-hydroxypyridine-2,6-dicarboxylate

Chemical Property:

• Melting Point: 166.0 to 170.0 °C
• Boiling Point: 349 °C at 760 mmHg
• PKA: 6.58±0.23(Predicted)
• Flash Point: 164.8 °C
• PSA: 85.46000
• Density: 1.346 g/cm³
• LogP: -0.05190

Purity/Quality:

97% ^*data from raw suppliers

Dimethyl 4-Hydroxy-2,6-pyridinedicarboxylate >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Dimethyl 4-hydroxypyridine-2,6-dicarboxylate

There total 12 articles about Dimethyl 4-hydroxypyridine-2,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + Chelidamic acid (499-51-4) → dimethyl 4-hydroxypyridine-2,6-dicarboxylate (19872-91-4)

Guidance literature:

With thionyl chloride; at 20 - 60 ℃; for 26h;

DOI:10.1021/acs.bioconjchem.9b00225

Reference yield: 95.0%

methanol (67-56-1) + chelidamic acid (138-60-3) → dimethyl 4-hydroxypyridine-2,6-dicarboxylate (19872-91-4)

Guidance literature:

With sulfuric acid; at 20 ℃; Reflux;

DOI:10.1021/ol102759w

Reference yield: 88.0%

Chelidamic acid (499-51-4) + 2,2-dimethoxy-propane (77-76-9) → dimethyl 4-hydroxypyridine-2,6-dicarboxylate (19872-91-4)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1039/c7ra09975d

upstream raw materials:

Chelidamic acid

methanol

chelidamic acid

chelidonic acid

Downstream raw materials:

1,3,5-Tris<<2,6-bis(methoxycarbonyl)-4-pyridinyloxy>methyl>-benzol

4-benzyloxypyridine-2,6-dicarboxylic dimethyl ester

C₂₆H₂₄N₂O₁₀

4-[3,5-bis(benzyloxy)benzyloxy]pyridine-2,6-dicarboxylic acid dimethyl ester