Technology Process of (R)-4-benzyl-3-(2-phenoxyethyl)morpholine hydrochloride
There total 5 articles about (R)-4-benzyl-3-(2-phenoxyethyl)morpholine hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dimethylsulfide borane complex;
In
tetrahydrofuran;
at 0 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 80 percent / NaOH, sodium borohydride / H2O / 0.5 h / 0 °C
2: 85 percent / 3.4M sodium bis(2-methoxyethoxy)aluminium hydride / toluene / 6 h / Heating
3: 1.) triethylamine, 2.) K t-butoxide / 1.) toluene, -3 deg C, 1 h, 22 deg C, 18 h; 2.) t-butyl alcohol, reflux, 6 h
4: 56 percent / borane-dimethyl sulphide / tetrahydrofuran / 18 h / 0 °C
With
sodium hydroxide; sodium tetrahydroborate; dimethylsulfide borane complex; potassium tert-butylate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; water; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 80 percent / NaOH, sodium borohydride / H2O / 0.5 h / 0 °C
2: 85 percent / 3.4M sodium bis(2-methoxyethoxy)aluminium hydride / toluene / 6 h / Heating
3: 1.) triethylamine, 2.) K t-butoxide / 1.) toluene, -3 deg C, 1 h, 22 deg C, 18 h; 2.) t-butyl alcohol, reflux, 6 h
4: 56 percent / borane-dimethyl sulphide / tetrahydrofuran / 18 h / 0 °C
With
sodium hydroxide; sodium tetrahydroborate; dimethylsulfide borane complex; potassium tert-butylate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; water; toluene;
