C₄₆H₆₅NO₇SSi

Base Information

Chemical Name:C₄₆H₆₅NO₇SSi
CAS No.:124665-53-8
Molecular Formula:C₄₆H₆₅NO₇SSi
Molecular Weight:804.176
Hs Code.:

C<sub>46</sub>H<sub>65</sub>NO<sub>7</sub>SSi

Synonyms:C₄₆H₆₅NO₇SSi

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Chemical Property of C₄₆H₆₅NO₇SSi

Chemical Property:

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Technology Process of C₄₆H₆₅NO₇SSi

There total 20 articles about C₄₆H₆₅NO₇SSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 124665-40-3
C₃₉H₅₉NO₅Si

: 98-59-9
p-toluenesulfonyl chloride

: 124665-53-8
C₄₆H₆₅NO₇SSi

Guidance literature:: With dmap; In pyridine; for 5.5h; Ambient temperature;
DOI:10.1016/S0040-4020(01)83440-2

Reference yield:

: 124665-33-4
(1R,2S,6S,7S)-2-Benzyloxymethyl-5-oxo-bicyclo[4.2.0]octane-7-carboxylic acid methyl ester

: 124665-53-8
C₄₆H₆₅NO₇SSi

Guidance literature:: Multi-step reaction with 18 steps

1: amberlyst 15 / 2 h / 0 °C

2: benzene; diethyl ether / 0.58 h

3: pyridinium p-toluenesulfonate / acetone / 0.33 h / Ambient temperature

4: 84 percent / N-ethyldiisopropylamine / CH₂Cl₂ / 46 h / Ambient temperature

5: sodium hydride / tetrahydrofuran / 6.5 h / Ambient temperature

6: triethylamine / 1.) 0 deg C, 1h; 2.) rt, 36h

7: potassium hydroxide / methanol; H₂O / 2.5 h / Heating

8: 87 percent / hydroxylamine hydrochloride, sodium acetate / methanol / 0.67 h / Heating

9: xylene / 0.83 h / 150 °C

10: sodium hydroxide / ethanol; H₂O / 7.25 h / Heating

11: 84 percent / H₂, (1S)-(+)-10-camphorsulfonic acid / palladium hydroxide on carbon / ethyl acetate / 22.5 h

12: 85 percent / N-ethyldiisopropylamine / 4-dimethylaminopyridine / CH₂Cl₂ / 1.) 0 deg C, 40 min; 2.) rt,1.33 h

13: lithium diisopropylamide / hexane; tetrahydrofuran / 1.) 0 deg C, 50 min; 2.) rt, 50 min

14: 83 percent / n-BuLi / hexane; tetrahydrofuran / 1.1 h / Ambient temperature

15: pyridinium p-toluenesulfonate / dimethylformamide / 0.83 h / Ambient temperature

16: sodium hydride / dimethylformamide / 1.25 h

17: 99 percent / acetic acid; tetrahydrofuran; propan-2-ol / 8.5 h / Ambient temperature

18: 94 percent / 4-dimethylaminopyridine / pyridine / 5.5 h / Ambient temperature

With dmap; potassium hydroxide; sodium hydroxide; n-butyllithium; Amberlyst 15; hydroxylamine hydrochloride; hydrogen; sodium acetate; pyridinium p-toluenesulfonate; sodium hydride; (+)-10-camphorsulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; dmap; palladium dihydroxide; In tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetone; xylene; benzene;
DOI:10.1016/S0040-4020(01)83440-2

Reference yield:

: 118378-03-3
(1S,5S,6R,8S)-5-Benzyloxymethyl-8-(1-hydroxy-1-methyl-ethyl)-bicyclo[4.2.0]octan-2-one

: 124665-53-8
C₄₆H₆₅NO₇SSi

Guidance literature:: Multi-step reaction with 15 steps

1: 84 percent / N-ethyldiisopropylamine / CH₂Cl₂ / 46 h / Ambient temperature

2: sodium hydride / tetrahydrofuran / 6.5 h / Ambient temperature

3: triethylamine / 1.) 0 deg C, 1h; 2.) rt, 36h

4: potassium hydroxide / methanol; H₂O / 2.5 h / Heating

5: 87 percent / hydroxylamine hydrochloride, sodium acetate / methanol / 0.67 h / Heating

6: xylene / 0.83 h / 150 °C

7: sodium hydroxide / ethanol; H₂O / 7.25 h / Heating

8: 84 percent / H₂, (1S)-(+)-10-camphorsulfonic acid / palladium hydroxide on carbon / ethyl acetate / 22.5 h

9: 85 percent / N-ethyldiisopropylamine / 4-dimethylaminopyridine / CH₂Cl₂ / 1.) 0 deg C, 40 min; 2.) rt,1.33 h

10: lithium diisopropylamide / hexane; tetrahydrofuran / 1.) 0 deg C, 50 min; 2.) rt, 50 min

11: 83 percent / n-BuLi / hexane; tetrahydrofuran / 1.1 h / Ambient temperature

12: pyridinium p-toluenesulfonate / dimethylformamide / 0.83 h / Ambient temperature

13: sodium hydride / dimethylformamide / 1.25 h

14: 99 percent / acetic acid; tetrahydrofuran; propan-2-ol / 8.5 h / Ambient temperature

15: 94 percent / 4-dimethylaminopyridine / pyridine / 5.5 h / Ambient temperature

With dmap; potassium hydroxide; sodium hydroxide; n-butyllithium; hydroxylamine hydrochloride; hydrogen; sodium acetate; pyridinium p-toluenesulfonate; sodium hydride; (+)-10-camphorsulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; dmap; palladium dihydroxide; In tetrahydrofuran; pyridine; methanol; ethanol; hexane; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; xylene;
DOI:10.1016/S0040-4020(01)83440-2