ethyl 2-methyl>amino>pyridine-3-carboxylate

Base Information

• Chemical Name: ethyl 2-methyl>amino>pyridine-3-carboxylate
• CAS No.: 141871-71-8
• Molecular Formula: C₂₅H₂₆N₆O₂
• Molecular Weight: 442.52
• Mol file: 141871-71-8.mol

Synonyms:ethyl 2-methyl>amino>pyridine-3-carboxylate

Chemical Property of ethyl 2-methyl>amino>pyridine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-methyl>amino>pyridine-3-carboxylate

There total 8 articles about ethyl 2-methyl>amino>pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

ethyl 2-biphenyl-4-yl)-methyl>amino>pyridine-3-carboxylate (141887-45-8) → ethyl 2-{N-propyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyridine-3-carboxylate (141871-71-8)

Guidance literature:

With hydrogenchloride; In ethanol;

Reference yield: 87.0%

ethyl 2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxylate (143618-27-3) → ethyl 2-methyl>amino>pyridine-3-carboxylate (141871-71-8)

Guidance literature:

With formic acid; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/jm00070a012

Reference yield:

2-Chloronicotinoyl chloride (49609-84-9) → ethyl 2-methyl>amino>pyridine-3-carboxylate (141871-71-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 0.33 h / Heating

2: 68 percent / ethanol / 6 h / 100 °C

3: 1.) 1,3-dimethyl-3,4,5,6-tetrahydro-2-pyrimidinone, LiN(TMS)2 / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 90 min

4: 87 percent / 88percent aq. HCOOH / CH₂Cl₂ / 2 h / Ambient temperature

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; formic acid; lithium hexamethyldisilazane; In ethanol; dichloromethane;

DOI:10.1021/jm00070a012

upstream raw materials:

ethyl 2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxylate

2-Chloronicotinoyl chloride

2-chloronicotinic acid

ethyl 2-chloronicotinate

Downstream raw materials:

A 81988