(S)-N-(2-(2-benzoyl-4-chlorophenylamino)-2-oxo-1-phenylethyl)-4-methylpiperazine-1-carbamide

Base Information

Chemical Name:(S)-N-(2-(2-benzoyl-4-chlorophenylamino)-2-oxo-1-phenylethyl)-4-methylpiperazine-1-carbamide
CAS No.:1295585-16-8
Molecular Formula:C₂₇H₂₇ClN₄O₃
Molecular Weight:490.989
Hs Code.:

Synonyms:(S)-N-(2-(2-benzoyl-4-chlorophenylamino)-2-oxo-1-phenylethyl)-4-methylpiperazine-1-carbamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-(2-(2-benzoyl-4-chlorophenylamino)-2-oxo-1-phenylethyl)-4-methylpiperazine-1-carbamide

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Technology Process of (S)-N-(2-(2-benzoyl-4-chlorophenylamino)-2-oxo-1-phenylethyl)-4-methylpiperazine-1-carbamide

There total 4 articles about (S)-N-(2-(2-benzoyl-4-chlorophenylamino)-2-oxo-1-phenylethyl)-4-methylpiperazine-1-carbamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 39539-66-7
4-methyl-piperazine-1-carbonyl chloride

: 1295585-08-8
(S)-N-(2-benzoyl-4-chlorophenyl)-phenylglycinamide hydrochloride

: 1295585-16-8
(S)-N-(2-(2-benzoyl-4-chlorophenylamino)-2-oxo-1-phenylethyl)-4-methylpiperazine-1-carbamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; Cooling with ice;
DOI:10.1016/j.ejmech.2011.01.056

Reference yield:

: 2900-27-8
(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

: 1295585-16-8
(S)-N-(2-(2-benzoyl-4-chlorophenylamino)-2-oxo-1-phenylethyl)-4-methylpiperazine-1-carbamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; trichlorophosphate / 0.5 h / -15 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

3: triethylamine / dichloromethane / 20 °C / Cooling with ice

With pyridine; hydrogenchloride; triethylamine; trichlorophosphate; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.ejmech.2011.01.056

Reference yield:

: 1295585-05-5
tert-butyl (S)-2-(2-benzoyl-4-chlorophenylamino)-2-oxo-1-phenylethylcarbamate

: 1295585-16-8
(S)-N-(2-(2-benzoyl-4-chlorophenylamino)-2-oxo-1-phenylethyl)-4-methylpiperazine-1-carbamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

2: triethylamine / dichloromethane / 20 °C / Cooling with ice

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.ejmech.2011.01.056