3-(1,3-dimethyl-2,4-dioxo-6-((2-(trimethylsilyl)ethoxy)methyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

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Chemical Name:3-(1,3-dimethyl-2,4-dioxo-6-((2-(trimethylsilyl)ethoxy)methyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile
CAS No.:1613623-83-8
Molecular Formula:C₂₁H₂₆N₄O₃Si
Molecular Weight:410.548
Hs Code.:

Synonyms:3-(1,3-dimethyl-2,4-dioxo-6-((2-(trimethylsilyl)ethoxy)methyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

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Chemical Property of 3-(1,3-dimethyl-2,4-dioxo-6-((2-(trimethylsilyl)ethoxy)methyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

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Technology Process of 3-(1,3-dimethyl-2,4-dioxo-6-((2-(trimethylsilyl)ethoxy)methyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

There total 5 articles about 3-(1,3-dimethyl-2,4-dioxo-6-((2-(trimethylsilyl)ethoxy)methyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6952-59-6
3-cyanobromobenzene

: 1613623-81-6
1,3-dimethyl-2,4-dioxo-6-((2-(trimethylsilyl)ethoxy)methyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-ylboronic acid

: 1613623-83-8
3-(1,3-dimethyl-2,4-dioxo-6-((2-(trimethylsilyl)ethoxy)methyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

Guidance literature:: With potassium carbonate; In acetic acid butyl ester; water; at 80 ℃; for 1.5h;

Reference yield:

: 1613623-79-2
1,3-dimethyl-6-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

: 1613623-83-8
3-(1,3-dimethyl-2,4-dioxo-6-((2-(trimethylsilyl)ethoxy)methyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C

1.2: 1.5 h / -78 °C

2.1: potassium carbonate / acetic acid butyl ester; water / 1.5 h / 80 °C

With n-butyllithium; potassium carbonate; diisopropylamine; In tetrahydrofuran; acetic acid butyl ester; water;

Reference yield:

: 874-14-6,156398-76-4
1,3-dimethyluracil

: 1613623-83-8
3-(1,3-dimethyl-2,4-dioxo-6-((2-(trimethylsilyl)ethoxy)methyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / 2-methyltetrahydrofuran / 0.67 h / 0 - 30 °C / Inert atmosphere

2.1: sodium hydride; N-benzyl-N,N,N-triethylammonium chloride / tetrahydrofuran; mineral oil / 18 h / 20 °C

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C

3.2: 1.5 h / -78 °C

4.1: potassium carbonate / acetic acid butyl ester; water / 1.5 h / 80 °C

With n-butyllithium; potassium tert-butylate; N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; potassium carbonate; diisopropylamine; In tetrahydrofuran; 2-methyltetrahydrofuran; acetic acid butyl ester; water; mineral oil;