3-(1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

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Chemical Name:3-(1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile
CAS No.:1613622-60-8
Molecular Formula:C₁₅H₁₂N₄O₂
Molecular Weight:280.286
Hs Code.:

Synonyms:3-(1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

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Chemical Property of 3-(1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

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Technology Process of 3-(1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

There total 5 articles about 3-(1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613623-83-8
3-(1,3-dimethyl-2,4-dioxo-6-((2-(trimethylsilyl)ethoxy)methyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

: 1613622-60-8
3-(1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 60 ℃; for 1h;

Reference yield:

: 1613623-81-6
1,3-dimethyl-2,4-dioxo-6-((2-(trimethylsilyl)ethoxy)methyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-ylboronic acid

: 1613622-60-8
3-(1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetic acid butyl ester; water / 1.5 h / 80 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 60 °C

With tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; acetic acid butyl ester; water;

Reference yield:

: 1396807-57-0
1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

: 1613622-60-8
3-(1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride; N-benzyl-N,N,N-triethylammonium chloride / tetrahydrofuran; mineral oil / 18 h / 20 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C

2.2: 1.5 h / -78 °C

3.1: potassium carbonate / acetic acid butyl ester; water / 1.5 h / 80 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 60 °C

With n-butyllithium; tetrabutyl ammonium fluoride; N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; potassium carbonate; diisopropylamine; In tetrahydrofuran; acetic acid butyl ester; water; mineral oil;