7-(4-chlorophenyl)-10-methylthio-5,6-dihydro-9H-benzo[h]pyrimido[4,5-b]quinolin-8-one

Base Information

• Chemical Name: 7-(4-chlorophenyl)-10-methylthio-5,6-dihydro-9H-benzo[h]pyrimido[4,5-b]quinolin-8-one
• CAS No.: 933467-70-0
• Molecular Formula: C₂₂H₁₆ClN₃OS
• Molecular Weight: 405.908

Synonyms:7-(4-chlorophenyl)-10-methylthio-5,6-dihydro-9H-benzo[h]pyrimido[4,5-b]quinolin-8-one

Chemical Property of 7-(4-chlorophenyl)-10-methylthio-5,6-dihydro-9H-benzo[h]pyrimido[4,5-b]quinolin-8-one

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 7-(4-chlorophenyl)-10-methylthio-5,6-dihydro-9H-benzo[h]pyrimido[4,5-b]quinolin-8-one

There total 2 articles about 7-(4-chlorophenyl)-10-methylthio-5,6-dihydro-9H-benzo[h]pyrimido[4,5-b]quinolin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

7-(4-chlorophenyl)-10-thioxo-5,6,10,11-tetrahydro-9H-benzo[h]pyrimido[4,5-b]quinolin-8-one (933467-66-4) + methyl iodide (74-88-4) → 7-(4-chlorophenyl)-10-methylthio-5,6-dihydro-9H-benzo[h]pyrimido[4,5-b]quinolin-8-one (933467-70-0)

Guidance literature:

7-(4-chlorophenyl)-10-thioxo-5,6,10,11-tetrahydro-9H-benzo[h]pyrimido[4,5-b]quinolin-8-one; With potassium hydroxide; In ethanol; for 0.5h; Heating;

methyl iodide; In ethanol; for 5h; Heating;

DOI:10.1080/10426500500543768

Reference yield:

2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one (49545-70-2,59082-24-5,59082-35-8) → 7-(4-chlorophenyl)-10-methylthio-5,6-dihydro-9H-benzo[h]pyrimido[4,5-b]quinolin-8-one (933467-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 51 percent / dimethylformamide / 20 h / Heating

2.1: KOH / ethanol / 0.5 h / Heating

2.2: 87 percent / ethanol / 5 h / Heating

With potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1080/10426500500543768

Reference yield: 72.0%

7-(4-chlorophenyl)-10-methylthio-5,6-dihydro-9H-benzo[h]pyrimido[4,5-b]quinolin-8-one (933467-70-0) → 7-(4-chlorophenyl)-10-hydrazino-5,6-dihydro-9H-benzo[h]pyrimido[4,5-b]quinolin-8-one (933467-71-1)

Guidance literature:

With hydrazine hydrate; In 1,4-dioxane; for 12h; Heating;

DOI:10.1080/10426500500543768

upstream raw materials:

7-(4-chlorophenyl)-10-thioxo-5,6,10,11-tetrahydro-9H-benzo[h]pyrimido[4,5-b]quinolin-8-one

methyl iodide

2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one

Downstream raw materials:

7-(4-chlorophenyl)-10-hydrazino-5,6-dihydro-9H-benzo[h]pyrimido[4,5-b]quinolin-8-one

7-(4-chlorophenyl)-5,6-dihydro-9H-benzo[h]tetrazolo[4',5':1,2]pyrimido[4,5-b]quinolin-8-one

7-(4-chlorophenyl)-10-(3-methyl-4H-pyrazol-5-on-1-yl)-5,6-dihydro-9H-benzo[h]pyrimido[4,5-b]quinolin-8-one

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