C₄₄H₄₉N₅O₁₂

Base Information

Chemical Name:C₄₄H₄₉N₅O₁₂
CAS No.:171762-83-7
Molecular Formula:C₄₄H₄₉N₅O₁₂
Molecular Weight:839.899
Hs Code.:

C<sub>44</sub>H<sub>49</sub>N<sub>5</sub>O<sub>12</sub>

Synonyms:C₄₄H₄₉N₅O₁₂

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Chemical Property of C₄₄H₄₉N₅O₁₂

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Technology Process of C₄₄H₄₉N₅O₁₂

There total 20 articles about C₄₄H₄₉N₅O₁₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 171762-82-6
N-[(2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-2-[(2S,3R,4R,5R)-2-hydroxymethyl-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetamide

: 171762-83-7
C₄₄H₄₉N₅O₁₂

Guidance literature:: With pyridine; for 24h; Ambient temperature;

Reference yield:

: 55486-09-4
2'-O-Methyl-5-methyluridine

: 171762-83-7
C₄₄H₄₉N₅O₁₂

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / I₂, PPh₃, pyridine / 5 h / Ambient temperature

2: 89 percent / NaN₃ / dimethylformamide / 24 h / 60 °C

3: 87 percent / DMAP, imidazole / dimethylformamide / 24 h / Ambient temperature

4: 72 percent / SnCl₂*2H₂O / methanol / 20 h / Ambient temperature

5: 1.) Et₃N, O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, HOBT, 2.) Et₃N / 1.) MeCN, THF, r.t., 1 h, 2.) r.t., 12 h

6: 91 percent / TBAF / tetrahydrofuran / 9 h / Ambient temperature

7: 88 percent / pyridine / 24 h / Ambient temperature

With pyridine; 1H-imidazole; dmap; sodium azide; tetrabutyl ammonium fluoride; iodine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; triphenylphosphine; tin(ll) chloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 22423-26-3
O-2,2'-cyclo-5-methyluridine

: 171762-83-7
C₄₄H₄₉N₅O₁₂

Guidance literature:: Multi-step reaction with 15 steps

1: 72 percent / imidazole / dimethylformamide / 18 h / Ambient temperature

2: 82 percent / Et₃N, DMAP, pyridine / CH₂Cl₂ / 40 h / Ambient temperature

3: 79 percent / AIBN / benzene / 20 h / Heating

4: 90 percent / aq. NaOH / tetrahydrofuran / 5 h / Ambient temperature

5: 92 percent / DBU / acetonitrile / 18 h / Ambient temperature

6: 83 percent / PPh₃, diisopropylazodicarboxylate / toluene / 50 h / Ambient temperature

7: 92 percent / NaOMe / methanol / 1 h / Ambient temperature

8: 94 percent / NaH / tetrahydrofuran / 17 h / Ambient temperature

9: 61 percent / OsO₄, N-methylmorpholine-N-oxide, H₂O / acetone / 18 h / Ambient temperature

10: 83 percent / H₂ / 10percent Pd/C / methanol / 18 h / 760 Torr / Ambient temperature

11: 81 percent / aq. NaIO₄ / dioxane / 18 h / Ambient temperature

12: 92 percent / aq. NaClO₂, NaH₂PO₄, 2-methyl-2-butene / 2-methyl-propan-2-ol / 30 h / Ambient temperature

13: 1.) Et₃N, O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, HOBT, 2.) Et₃N / 1.) MeCN, THF, r.t., 1 h, 2.) r.t., 12 h

14: 91 percent / TBAF / tetrahydrofuran / 9 h / Ambient temperature

15: 88 percent / pyridine / 24 h / Ambient temperature

With pyridine; 1H-imidazole; dmap; sodium hydroxide; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; 2,2'-azobis(isobutyronitrile); di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; water; hydrogen; sodium methylate; sodium hydride; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; tert-butyl alcohol; benzene;