1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indol-4-yl]-3-(5-chloro-2-methoxyphenyl)urea hydrochloride

Base Information

Chemical Name:1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indol-4-yl]-3-(5-chloro-2-methoxyphenyl)urea hydrochloride
CAS No.:1362852-56-9
Molecular Formula:C₂₂H₂₀ClN₅O₂*ClH
Molecular Weight:460.331
Hs Code.:

Synonyms:1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indol-4-yl]-3-(5-chloro-2-methoxyphenyl)urea hydrochloride

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Chemical Property of 1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indol-4-yl]-3-(5-chloro-2-methoxyphenyl)urea hydrochloride

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Technology Process of 1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indol-4-yl]-3-(5-chloro-2-methoxyphenyl)urea hydrochloride

There total 14 articles about 1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indol-4-yl]-3-(5-chloro-2-methoxyphenyl)urea hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1362855-50-2
C₂₇H₂₆⁽²⁾H₂ClN₅O₄

: 1362852-56-9
1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indol-4-yl]-3-(5-chloro-2-methoxyphenyl)urea hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; at 60 ℃;

Reference yield:

: 54221-95-3
2-(acetylamino)isonicotinic acid

: 1362852-56-9
1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indol-4-yl]-3-(5-chloro-2-methoxyphenyl)urea hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: boron trifluoride diethyl etherate / ethanol / Reflux

2: tert-butyl alcohol / 16 h / 60 °C

3: calcium chloride; sodium borodeuteride / d⁽⁴⁾-methanol / 0 - 20 °C

4: carbon tetrabromide; triphenylphosphine / dichloromethane / 0 - 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 80 °C

6: 2,3-dicyano-5,6-dichloro-p-benzoquinone / acetone / 20 °C

7: hydrogenchloride / methanol / 60 °C

With hydrogenchloride; sodium borodeuteride; carbon tetrabromide; boron trifluoride diethyl etherate; potassium carbonate; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; calcium chloride; In methanol; ethanol; dichloromethane; d⁽⁴⁾-methanol; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;

Reference yield:

: 1362855-33-1
C₁₁H₁₄⁽²⁾H₂N₂O₃

: 1362852-56-9
1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indol-4-yl]-3-(5-chloro-2-methoxyphenyl)urea hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 80 °C

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / acetone / 20 °C

4: hydrogenchloride / methanol / 60 °C

With hydrogenchloride; carbon tetrabromide; potassium carbonate; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;