Technology Process of 1-Benzyl-3-(5-methoxypyridin-2-ylmethyl)-1H-indol
There total 8 articles about 1-Benzyl-3-(5-methoxypyridin-2-ylmethyl)-1H-indol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
hydrogenchloride; ethanol;
at 20 ℃;
for 3h;
under 52504.2 Torr;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 77 percent / NaOH; TBAHS; KI / CH2Cl2 / Heating
2.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -105 - -100 °C
2.2: 60 percent / tetrahydrofuran; hexane / 1.5 h / -100 °C
3.1: 100 percent / H2 / 5 percent Pd/C / ethanol; aq. HCl / 3 h / 20 °C / 52504.2 Torr
With
sodium hydroxide; n-butyllithium; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; potassium iodide;
palladium on activated charcoal;
In
tetrahydrofuran; hydrogenchloride; ethanol; hexane; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 80 percent / conc. H2SO4; fum. HNO3 / 4 h / 50 °C
2.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
3.1: Br2 / aq. HBr / cooling
3.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
4.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -105 - -100 °C
4.2: 60 percent / tetrahydrofuran; hexane / 1.5 h / -100 °C
5.1: 100 percent / H2 / 5 percent Pd/C / ethanol; aq. HCl / 3 h / 20 °C / 52504.2 Torr
With
n-butyllithium; sulfuric acid; hydrogen; bromine; nitric acid; hydrazine hydrate;
palladium on activated charcoal;
In
tetrahydrofuran; hydrogenchloride; ethanol; hexane; hydrogen bromide;
