6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester

Base Information

• Chemical Name: 6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester
• CAS No.: 849752-39-2
• Molecular Formula: C₃₂H₃₃F₃N₂O₈S
• Molecular Weight: 662.684
• Mol file: 849752-39-2.mol

Synonyms:6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester

Chemical Property of 6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester

There total 1 articles about 6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C10H8ClF3O4S + Nε-(9-fluorenylmethoxycarbonyl)-L-lysine methyl ester hydrochloride (201009-98-5) → 6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester (849752-39-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tet.2004.12.052

Reference yield: 82.0%

6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester (849752-39-2) → (S)-2-Amino-6-[2-(4-trifluoromethyl-benzenesulfonyl)-ethylamino]-hexanoic acid methyl ester

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 50 ℃; for 4h;

DOI:10.1016/j.tet.2004.12.052

Reference yield:

6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester (849752-39-2) + 1-Methylpyrrolidine (120-94-5) → 1-[2-(4-trifluoromethyl-benzenesulfonyl)-ethyl]-pyrrolidine + (S)-2-[2-(4-Trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-6-[2-(4-trifluoromethyl-benzenesulfonyl)-ethylamino]-hexanoic acid methyl ester

Guidance literature:

In N,N-dimethyl-formamide; at 25 ℃; for 1h;

DOI:10.1016/j.tet.2004.12.052

upstream raw materials:

N^ε-(9-fluorenylmethoxycarbonyl)-L-lysine methyl ester hydrochloride

Downstream raw materials:

N-(fluorenyl-9-methoxycarbonyl)-L-lysine

N_ε-<(fluoren-9-ylmethoxy)carbonyl>lysine methyl ester