3-hydroxy-3-benzylpropanenitrile

Base Information

• Chemical Name: 3-hydroxy-3-benzylpropanenitrile
• CAS No.: 6732-41-8
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.203
• Mol file: 6732-41-8.mol

Synonyms:3-hydroxy-3-benzylpropanenitrile

Chemical Property of 3-hydroxy-3-benzylpropanenitrile

Chemical Property:

Purity/Quality:

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• Pictogram(s):  
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MSDS Files:

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Technology Process of 3-hydroxy-3-benzylpropanenitrile

There total 7 articles about 3-hydroxy-3-benzylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,2-epoxy-3-phenylpropane (4436-24-2) + sodium cyanide (143-33-9,25596-52-5) → 3-hydroxy-3-benzylpropanenitrile (6732-41-8)

Guidance literature:

With ammonium chloride; In methanol; water; at 85 ℃; for 15h;

DOI:10.1002/1615-4169(200108)343:6/7<726::aid-adsc726>3.3.co;2-5

Reference yield: 65.0%

potassium cyanide + 1-chloro-3-phenylpropan-2-ol (5396-65-6) → 3-hydroxy-3-benzylpropanenitrile (6732-41-8)

Guidance literature:

With sodium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 20h;

DOI:10.1021/jacs.0c01890

Reference yield:

5-benzyl-4,5-dihydro-1,2-oxazole (1412494-25-7) → 3-hydroxy-3-benzylpropanenitrile (6732-41-8)

Guidance literature:

With aluminum oxide; In methanol; diethyl ether; chloroform; at 20 ℃;

DOI:10.1134/S1070428016030179

upstream raw materials:

1-chloro-3-phenylpropan-2-ol

potassium cyanide

1,2-epoxy-3-phenylpropane

sodium cyanide

Downstream raw materials:

3-hydroxy-4-phenylbutanoic acid ethyl ester

3-allylloxy-4-phenylbutyronitrile

4-Phenyl-3-hydroxy-buttersaeureamid