<1R-(1α,2β,3β)>-3-hydroxy-1,2-cyclobutanedimethanol 1,2-dibenzoate ester

Base Information

Chemical Name:<1R-(1α,2β,3β)>-3-hydroxy-1,2-cyclobutanedimethanol 1,2-dibenzoate ester
CAS No.:132294-25-8
Molecular Formula:C₂₀H₂₀O₅
Molecular Weight:340.376
Hs Code.:

Synonyms:<1R-(1α,2β,3β)>-3-hydroxy-1,2-cyclobutanedimethanol 1,2-dibenzoate ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of <1R-(1α,2β,3β)>-3-hydroxy-1,2-cyclobutanedimethanol 1,2-dibenzoate ester

Chemical Property:

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Technology Process of <1R-(1α,2β,3β)>-3-hydroxy-1,2-cyclobutanedimethanol 1,2-dibenzoate ester

There total 13 articles about <1R-(1α,2β,3β)>-3-hydroxy-1,2-cyclobutanedimethanol 1,2-dibenzoate ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.4%

: 124770-80-5,126261-72-1,132294-16-7,132294-24-7
trans-2,3-bis(benzoyloxymethyl)cyclobutanone

: 126261-73-2,126373-88-4,127759-90-4,127759-93-7,132294-17-8,132294-25-8
C₂₀H₂₀O₅

Guidance literature:: With lithium tri-sec-butyl(hydrido)borate; In tetrahydrofuran; at -78 ℃; for 3h; Inert atmosphere;

Reference yield: 70.0%

: 132294-24-7
(2R-trans)-2,3-bis<(benzoyloxy)methyl>cyclobutanone

: 132294-25-8
<1R-(1α,2β,3β)>-3-hydroxy-1,2-cyclobutanedimethanol 1,2-dibenzoate ester

Guidance literature:: With lithium tri-sec-butyl(hydrido)borate; In tetrahydrofuran; at -78 ℃; for 0.166667h;
DOI:10.1021/jm00108a026

Reference yield:

: 132178-71-3
trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid

: 132294-25-8
<1R-(1α,2β,3β)>-3-hydroxy-1,2-cyclobutanedimethanol 1,2-dibenzoate ester

Guidance literature:: Multi-step reaction with 5 steps

1: DCC / CH₂Cl₂ / Ambient temperature

2: imidazole / dimethylformamide / 1.5 h / 5 °C

3: N₂O₄, NaOAc / CCl₄ / 0.25 h / 5 °C

4: 95 percent / 0.5 N H₂SO₄ / acetonitrile / 17 h / Ambient temperature

5: 70 percent / LS-Selectride / tetrahydrofuran / 0.17 h / -78 °C

With 1H-imidazole; sulfuric acid; sodium acetate; dinitrogen tetraoxide; lithium tri-sec-butyl(hydrido)borate; dicyclohexyl-carbodiimide; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00108a026