[1S-[1α(S),2β(S)]]-N,N'-Bis[2-[[(1,1-dimethylethyl) dimethylsilyl]oxy]-1-phenylethyl]-3,3-diethoxy-1,2-cyclobutanedicarboxamide

Base Information

Chemical Name:[1S-[1α(S*),2β(S*)]]-N,N'-Bis[2-[[(1,1-dimethylethyl) dimethylsilyl]oxy]-1-phenylethyl]-3,3-diethoxy-1,2-cyclobutanedicarboxamide
CAS No.:132178-73-5
Molecular Formula:C₃₈H₆₂N₂O₆Si₂
Molecular Weight:699.091
Hs Code.:

Synonyms:[1S-[1α(S*),2β(S*)]]-N,N'-Bis[2-[[(1,1-dimethylethyl) dimethylsilyl]oxy]-1-phenylethyl]-3,3-diethoxy-1,2-cyclobutanedicarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [1S-[1α(S*),2β(S*)]]-N,N'-Bis[2-[[(1,1-dimethylethyl) dimethylsilyl]oxy]-1-phenylethyl]-3,3-diethoxy-1,2-cyclobutanedicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
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MSDS Files:: SDS file from LookChem

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Technology Process of [1S-[1α(S*),2β(S*)]]-N,N'-Bis[2-[[(1,1-dimethylethyl) dimethylsilyl]oxy]-1-phenylethyl]-3,3-diethoxy-1,2-cyclobutanedicarboxamide

There total 4 articles about [1S-[1α(S*),2β(S*)]]-N,N'-Bis[2-[[(1,1-dimethylethyl) dimethylsilyl]oxy]-1-phenylethyl]-3,3-diethoxy-1,2-cyclobutanedicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132178-72-4
<1S-<1α(S^*),2β(S^*)>>-3,3-diethoxy-N,N'-bis-(2-hydroxy-1-phenylethyl)-1,2-cyclobutanedicarboxamide

: 18162-48-6
tert-butyldimethylsilyl chloride

: 132178-73-5
[1S-[1α(S*),2β(S*)]]-N,N'-Bis[2-[[(1,1-dimethylethyl) dimethylsilyl]oxy]-1-phenylethyl]-3,3-diethoxy-1,2-cyclobutanedicarboxamide

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 5 ℃; for 1.5h;
DOI:10.1021/jm00108a026

Reference yield:

: 132178-71-3
trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid

: 132178-73-5
[1S-[1α(S*),2β(S*)]]-N,N'-Bis[2-[[(1,1-dimethylethyl) dimethylsilyl]oxy]-1-phenylethyl]-3,3-diethoxy-1,2-cyclobutanedicarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: DCC / CH₂Cl₂ / Ambient temperature

2: imidazole / dimethylformamide / 1.5 h / 5 °C

With 1H-imidazole; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00108a026

Reference yield:

: 127696-10-0
trans-3,3-diethoxy-1,2-cyclobutanedicarboxylic acid diethyl ester

: 132178-73-5
[1S-[1α(S*),2β(S*)]]-N,N'-Bis[2-[[(1,1-dimethylethyl) dimethylsilyl]oxy]-1-phenylethyl]-3,3-diethoxy-1,2-cyclobutanedicarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / 2 N KOH / methanol / 1 h / 43 °C

2: DCC / CH₂Cl₂ / Ambient temperature

3: imidazole / dimethylformamide / 1.5 h / 5 °C

With 1H-imidazole; potassium hydroxide; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00108a026