benzyl (2S)-2-[[(tert-butoxycarbonyl)amino]methyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate

Base Information

Chemical Name:benzyl (2S)-2-[[(tert-butoxycarbonyl)amino]methyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate
CAS No.:356535-16-5
Molecular Formula:C₂₄H₃₃N₃O₇
Molecular Weight:475.542
Hs Code.:

Synonyms:benzyl (2S)-2-[[(tert-butoxycarbonyl)amino]methyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate

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Chemical Property of benzyl (2S)-2-[[(tert-butoxycarbonyl)amino]methyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate

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Technology Process of benzyl (2S)-2-[[(tert-butoxycarbonyl)amino]methyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate

There total 2 articles about benzyl (2S)-2-[[(tert-butoxycarbonyl)amino]methyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(2-benzyloxycarbonylamino-3-tert-butoxycarbonylamino-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetic acid tert-butyl ester

: 356535-16-5
benzyl (2S)-2-[[(tert-butoxycarbonyl)amino]methyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate

Guidance literature:: With toluene-4-sulfonic acid; In toluene; at 75 ℃; for 4h;
DOI:10.1021/jm0004345

Reference yield:

: 16947-84-5,62234-36-0
N-[(benzyloxy)carbonyl]-3-[(tert-butoxycarbonyl)amino]-L-alanine

: 356535-16-5
benzyl (2S)-2-[[(tert-butoxycarbonyl)amino]methyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: EDC / CH₂Cl₂ / 2 h / 20 °C

2: p-toluenesulfonic acid monohydrate / toluene / 4 h / 75 °C

With toluene-4-sulfonic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; toluene;
DOI:10.1021/jm0004345

Reference yield:

: 356535-16-5
benzyl (2S)-2-[[(tert-butoxycarbonyl)amino]methyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate

: [(S)-3-Aminomethyl-4-(2-benzyloxycarbonylamino-acetyl)-2-oxo-piperazin-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / ethyl acetate / 2 h

2: EDC / CH₂Cl₂ / 1 h / 20 °C

3: TFA / toluene / 1 h / 20 °C

With hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; 10percent Pd/C; In dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jm0004345