{(S)-4-(2-Benzyloxycarbonylamino-acetyl)-3-[(4-guanidino-benzoylamino)-methyl]-2-oxo-piperazin-1-yl}-acetic acid

Base Information

Chemical Name:{(S)-4-(2-Benzyloxycarbonylamino-acetyl)-3-[(4-guanidino-benzoylamino)-methyl]-2-oxo-piperazin-1-yl}-acetic acid
CAS No.:1026864-00-5
Molecular Formula:C₂₅H₂₉N₇O₇
Molecular Weight:539.548
Hs Code.:

Synonyms:{(S)-4-(2-Benzyloxycarbonylamino-acetyl)-3-[(4-guanidino-benzoylamino)-methyl]-2-oxo-piperazin-1-yl}-acetic acid

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Chemical Property of {(S)-4-(2-Benzyloxycarbonylamino-acetyl)-3-[(4-guanidino-benzoylamino)-methyl]-2-oxo-piperazin-1-yl}-acetic acid

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Technology Process of {(S)-4-(2-Benzyloxycarbonylamino-acetyl)-3-[(4-guanidino-benzoylamino)-methyl]-2-oxo-piperazin-1-yl}-acetic acid

There total 5 articles about {(S)-4-(2-Benzyloxycarbonylamino-acetyl)-3-[(4-guanidino-benzoylamino)-methyl]-2-oxo-piperazin-1-yl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 356535-16-5
benzyl (2S)-2-[[(tert-butoxycarbonyl)amino]methyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate

: 1026864-00-5
{(S)-4-(2-Benzyloxycarbonylamino-acetyl)-3-[(4-guanidino-benzoylamino)-methyl]-2-oxo-piperazin-1-yl}-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10percent Pd/C / ethyl acetate / 2 h

2: EDC / CH₂Cl₂ / 1 h / 20 °C

3: TFA / toluene / 1 h / 20 °C

4: aq. NaHCO₃ / dioxane / 1 h / 20 °C

With hydrogen; sodium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; 10percent Pd/C; In 1,4-dioxane; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jm0004345

Reference yield:

: [(S)-3-Aminomethyl-4-(2-benzyloxycarbonylamino-acetyl)-2-oxo-piperazin-1-yl]-acetic acid

: 4-guanidinobenzoic acid 3,5-dioxo-4-azatricyclo[5.2.1.0.2,6)deca-8-en-4-yl ester hydrochloride

: 1026864-00-5
{(S)-4-(2-Benzyloxycarbonylamino-acetyl)-3-[(4-guanidino-benzoylamino)-methyl]-2-oxo-piperazin-1-yl}-acetic acid

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; at 20 ℃; for 1h;
DOI:10.1021/jm0004345

Reference yield:

: 42823-46-1
4-guanidinobenzoic acid hydrochloride

: 1026864-00-5
{(S)-4-(2-Benzyloxycarbonylamino-acetyl)-3-[(4-guanidino-benzoylamino)-methyl]-2-oxo-piperazin-1-yl}-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / 1,3-dicyclohexylcarbodiimide / dimethylformamide / 2 h / 20 °C

2: aq. NaHCO₃ / dioxane / 1 h / 20 °C

With sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm0004345