2-[3-(5-Isopropyl-4-phenyl-imidazol-1-yl)-propoxy]-6-methyl-phenylamine

Base Information

Chemical Name:2-[3-(5-Isopropyl-4-phenyl-imidazol-1-yl)-propoxy]-6-methyl-phenylamine
CAS No.:1026653-23-5
Molecular Formula:C₂₂H₂₇N₃O
Molecular Weight:349.476
Hs Code.:

Synonyms:2-[3-(5-Isopropyl-4-phenyl-imidazol-1-yl)-propoxy]-6-methyl-phenylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[3-(5-Isopropyl-4-phenyl-imidazol-1-yl)-propoxy]-6-methyl-phenylamine

Chemical Property:

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Technology Process of 2-[3-(5-Isopropyl-4-phenyl-imidazol-1-yl)-propoxy]-6-methyl-phenylamine

There total 7 articles about 2-[3-(5-Isopropyl-4-phenyl-imidazol-1-yl)-propoxy]-6-methyl-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027578-90-0
5-Isopropyl-1-[3-(3-methyl-2-nitro-phenoxy)-propyl]-4-phenyl-1H-imidazole

: 1026653-23-5
2-[3-(5-Isopropyl-4-phenyl-imidazol-1-yl)-propoxy]-6-methyl-phenylamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; for 3h;
DOI:10.1021/jm00063a014

Reference yield:

: 147749-67-5,50735-03-0
2-bromo-3-methyl-1-phenylbutan-1-one

: 1026653-23-5
2-[3-(5-Isopropyl-4-phenyl-imidazol-1-yl)-propoxy]-6-methyl-phenylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 60 deg C, 1 h, 2.) DMF, 1 h

2: ammonium formate, formic acid, formamide / 2 h / 120 °C

3: H₂ / 10percent Pd/C / ethyl acetate; ethanol / 3 h

With formic acid; hydrogen; ammonium formate; sodium hydride; formamide; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1021/jm00063a014

Reference yield:

: 4920-77-8
3-methyl-2-nitrophenol

: 1026653-23-5
2-[3-(5-Isopropyl-4-phenyl-imidazol-1-yl)-propoxy]-6-methyl-phenylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / K₂CO₃ / dimethylformamide / 2 h / 60 °C

2: 90 percent / NaI / dimethylformamide / 1 h / 100 °C

3: 86 percent / KOH / ethanol / 0.17 h / Ambient temperature

4: 1.) NaH / 1.) DMF, 60 deg C, 1 h, 2.) DMF, 1 h

5: ammonium formate, formic acid, formamide / 2 h / 120 °C

6: H₂ / 10percent Pd/C / ethyl acetate; ethanol / 3 h

With potassium hydroxide; formic acid; hydrogen; ammonium formate; sodium hydride; potassium carbonate; formamide; sodium iodide; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00063a014