2-(2-Benzyloxycarbonylamino-3-methanesulfonyloxy-butyrylamino)-3-methyl-but-2-enoic acid ethyl ester

Base Information

• Chemical Name: 2-(2-Benzyloxycarbonylamino-3-methanesulfonyloxy-butyrylamino)-3-methyl-but-2-enoic acid ethyl ester
• CAS No.: 78464-40-1
• Molecular Formula: C₂₀H₂₈N₂O₈S
• Molecular Weight: 456.517
• Mol file: 78464-40-1.mol

Synonyms:2-(2-Benzyloxycarbonylamino-3-methanesulfonyloxy-butyrylamino)-3-methyl-but-2-enoic acid ethyl ester

Chemical Property of 2-(2-Benzyloxycarbonylamino-3-methanesulfonyloxy-butyrylamino)-3-methyl-but-2-enoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-Benzyloxycarbonylamino-3-methanesulfonyloxy-butyrylamino)-3-methyl-but-2-enoic acid ethyl ester

There total 3 articles about 2-(2-Benzyloxycarbonylamino-3-methanesulfonyloxy-butyrylamino)-3-methyl-but-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methanesulfonyl chloride (124-63-0) + 2-(2-Benzyloxycarbonylamino-3-hydroxy-butyrylamino)-3-methyl-but-2-enoic acid ethyl ester (78464-34-3) → 2-(2-Benzyloxycarbonylamino-3-methanesulfonyloxy-butyrylamino)-3-methyl-but-2-enoic acid ethyl ester (78464-40-1)

Guidance literature:

With triethylamine; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1246/bcsj.54.1132

Reference yield:

α,β-dehydrovaline ethylester (22078-04-2) → 2-(2-Benzyloxycarbonylamino-3-methanesulfonyloxy-butyrylamino)-3-methyl-but-2-enoic acid ethyl ester (78464-40-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 20 h / Ambient temperature

2: 88 percent / triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1246/bcsj.54.1132

Reference yield:

2-benzyloxycarbonylamino-3-hydroxy-butyric acid (5618-95-1,19728-63-3,41151-16-0,80384-27-6,85995-53-5,119221-16-8) → 2-(2-Benzyloxycarbonylamino-3-methanesulfonyloxy-butyrylamino)-3-methyl-but-2-enoic acid ethyl ester (78464-40-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 20 h / Ambient temperature

2: 88 percent / triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1246/bcsj.54.1132

upstream raw materials:

methanesulfonyl chloride

2-(2-Benzyloxycarbonylamino-3-hydroxy-butyrylamino)-3-methyl-but-2-enoic acid ethyl ester

α,β-dehydrovaline ethylester

2-benzyloxycarbonylamino-3-hydroxy-butyric acid

Downstream raw materials:

2-((E)-2-Benzyloxycarbonylamino-but-2-enoylamino)-3-methyl-but-2-enoic acid ethyl ester