Benzyl-[(E)-2-((2R,4R,6R)-6-{(2R,4R,6R)-6-[(E)-(3S,4S)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-vinyl]-dimethyl-silane

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Chemical Name:Benzyl-[(E)-2-((2R,4R,6R)-6-{(2R,4R,6R)-6-[(E)-(3S,4S)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-vinyl]-dimethyl-silane
CAS No.:858676-90-1
Molecular Formula:C₄₈H₆₀O₆Si
Molecular Weight:761.086
Hs Code.:

Benzyl-[(E)-2-((2R,4R,6R)-6-{(2R,4R,6R)-6-[(E)-(3S,4S)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-vinyl]-dimethyl-silane

Synonyms:Benzyl-[(E)-2-((2R,4R,6R)-6-{(2R,4R,6R)-6-[(E)-(3S,4S)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-vinyl]-dimethyl-silane

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Chemical Property of Benzyl-[(E)-2-((2R,4R,6R)-6-{(2R,4R,6R)-6-[(E)-(3S,4S)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-vinyl]-dimethyl-silane

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Technology Process of Benzyl-[(E)-2-((2R,4R,6R)-6-{(2R,4R,6R)-6-[(E)-(3S,4S)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-vinyl]-dimethyl-silane

There total 11 articles about Benzyl-[(E)-2-((2R,4R,6R)-6-{(2R,4R,6R)-6-[(E)-(3S,4S)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-vinyl]-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-(2S,4R,7S,8S)-1-{(2R,4R,6R)-6-[(E)-2-(Benzyl-dimethyl-silanyl)-vinyl]-2-phenyl-[1,3]dioxan-4-yl}-8-(4-methoxy-benzyloxy)-7,9-dimethyl-dec-5-ene-2,4-diol

: 1125-88-8
benzaldehyde dimethyl acetal

: 858676-90-1
Benzyl-[(E)-2-((2R,4R,6R)-6-{(2R,4R,6R)-6-[(E)-(3S,4S)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-vinyl]-dimethyl-silane

Guidance literature:: With DL-10-camphorsulfonic acid; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/ja052226d

Reference yield:

: 858676-59-2
(2E)-3-[benzyl(dimethyl)silyl]acrylaldehyde

: 858676-90-1
Benzyl-[(E)-2-((2R,4R,6R)-6-{(2R,4R,6R)-6-[(E)-(3S,4S)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-vinyl]-dimethyl-silane

Guidance literature:: Multi-step reaction with 8 steps

1.1: 75 percent / SiCl₄; diisopropylethylamine; (R,R)-bisphosphoramide / CH₂Cl₂ / 3 h / -70 °C

2.1: 74 percent / KHMDS / tetrahydrofuran / 1 h / 0 °C

3.1: 87 percent / i-PrMgCl / tetrahydrofuran / -20 °C

4.1: 90 percent / MeMgBr / diethyl ether / 0 - 20 °C

5.1: 94 percent / DIPEA

6.1: SiCl₄; Hg(OAc)2

6.2: chiral cyclic phosphoramide derivative

7.1: Et₂BOMe / tetrahydrofuran; methanol / 0.25 h / -72 °C

7.2: NaBH₄ / tetrahydrofuran; methanol / 4 h / -72 °C

8.1: 2.79 g / dl-camphorosulfonic acid / CH₂Cl₂ / 16 h / 20 °C

With tetrachlorosilane; DL-10-camphorsulfonic acid; (R,R)-bisphosphoramide; diethyl methoxy borane; methylmagnesium bromide; mercury(II) diacetate; isopropylmagnesium chloride; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/ja052226d

Reference yield:

: 858676-57-0
(5R)-ethyl-7-benzyldimethylsilyl-5-hydroxy-hepta-2,6-dienoate

: 858676-90-1
Benzyl-[(E)-2-((2R,4R,6R)-6-{(2R,4R,6R)-6-[(E)-(3S,4S)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2-phenyl-[1,3]dioxan-4-ylmethyl}-2-phenyl-[1,3]dioxan-4-yl)-vinyl]-dimethyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1.1: 74 percent / KHMDS / tetrahydrofuran / 1 h / 0 °C

2.1: 87 percent / i-PrMgCl / tetrahydrofuran / -20 °C

3.1: 90 percent / MeMgBr / diethyl ether / 0 - 20 °C

4.1: 94 percent / DIPEA

5.1: SiCl₄; Hg(OAc)2

5.2: chiral cyclic phosphoramide derivative

6.1: Et₂BOMe / tetrahydrofuran; methanol / 0.25 h / -72 °C

6.2: NaBH₄ / tetrahydrofuran; methanol / 4 h / -72 °C

7.1: 2.79 g / dl-camphorosulfonic acid / CH₂Cl₂ / 16 h / 20 °C

With tetrachlorosilane; DL-10-camphorsulfonic acid; diethyl methoxy borane; methylmagnesium bromide; mercury(II) diacetate; isopropylmagnesium chloride; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/ja052226d