8-amino-7-(4-bromo-2-fluoro-phenylamino)-2,3-dihydro-1H-indolizin-5-one

Base Information

Chemical Name:8-amino-7-(4-bromo-2-fluoro-phenylamino)-2,3-dihydro-1H-indolizin-5-one
CAS No.:1193488-79-7
Molecular Formula:C₁₄H₁₃BrFN₃O
Molecular Weight:338.179
Hs Code.:

Synonyms:8-amino-7-(4-bromo-2-fluoro-phenylamino)-2,3-dihydro-1H-indolizin-5-one

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Chemical Property of 8-amino-7-(4-bromo-2-fluoro-phenylamino)-2,3-dihydro-1H-indolizin-5-one

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Technology Process of 8-amino-7-(4-bromo-2-fluoro-phenylamino)-2,3-dihydro-1H-indolizin-5-one

There total 1 articles about 8-amino-7-(4-bromo-2-fluoro-phenylamino)-2,3-dihydro-1H-indolizin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1193488-00-4
[7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizin-8-yl]-carbamic acid tert-butyl ester

: 1193488-79-7
8-amino-7-(4-bromo-2-fluoro-phenylamino)-2,3-dihydro-1H-indolizin-5-one

Guidance literature:: [7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizin-8-yl]-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at -10 - 20 ℃; for 4.08333h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 1193488-79-7
8-amino-7-(4-bromo-2-fluoro-phenylamino)-2,3-dihydro-1H-indolizin-5-one

: 4837-38-1
cyclohexanesulfonyl chloride

: 1193488-01-5
cyclohexanesulfonic acid [7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizin-8-yl]-amide

Guidance literature:: 8-amino-7-(4-bromo-2-fluoro-phenylamino)-2,3-dihydro-1H-indolizin-5-one; With pyridine; In dichloromethane; for 0.166667h; Inert atmosphere;

cyclohexanesulfonyl chloride; With dmap; In dichloromethane; at 0 - 20 ℃; for 16.1667h;

Reference yield:

: 1193488-79-7
8-amino-7-(4-bromo-2-fluoro-phenylamino)-2,3-dihydro-1H-indolizin-5-one

: 13360-57-1
dimethylamino sulfonyl chloride

: 1193488-03-7
N-[7-(4-bromo-2-fluoro-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizin-8-yl]-(N,N-dimethylamino)sulfonamide

Guidance literature:: 8-amino-7-(4-bromo-2-fluoro-phenylamino)-2,3-dihydro-1H-indolizin-5-one; dimethylamino sulfonyl chloride; With dmap; In tetrahydrofuran; at -35 - 20 ℃;

With pyridine; In tetrahydrofuran; at 40 ℃; for 4h;