5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazole

Base Information

Chemical Name:5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazole
CAS No.:1415991-91-1
Molecular Formula:C₂₅H₂₅FN₄O₃S
Molecular Weight:480.563
Hs Code.:

Synonyms:5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazole

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Chemical Property of 5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazole

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Technology Process of 5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazole

There total 7 articles about 5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[2-fluoro-4-(methylsulfonyl)phenyl]-5-(piperidin-4-yl)benzo[d]oxazole 2,2,2-trifluoroacetate

: 111196-81-7
2-chloro-5-ethylpyrimidine

: 1415991-91-1
5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazole

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 90 ℃; for 12h;

Reference yield:

: 142994-04-5
2-fluoro-4-(methylsulphonyl)benzoic acid

: 1415991-91-1
5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: polyposphoric acid / 3.5 h / 195 °C

1.2: pH 9

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12 h / 105 °C / Inert atmosphere

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere; Microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / methanol / 14 h / 2844.39 Torr

5.1: dichloromethane / 3 h / 25 - 28 °C

6.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 12 h / 90 °C

With hydrogen; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; 3.1: Suzuki Coupling;

Reference yield:

: 40925-68-6
2-amino-4-bromo-phenol

: 1415991-91-1
5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: polyposphoric acid / 3.5 h / 195 °C

1.2: pH 9

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12 h / 105 °C / Inert atmosphere

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere; Microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / methanol / 14 h / 2844.39 Torr

5.1: dichloromethane / 3 h / 25 - 28 °C

6.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 12 h / 90 °C

With hydrogen; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; 3.1: Suzuki Coupling;