2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N⁶-dimethylaminomethylene[1'-2H]adenosine

Base Information

• Chemical Name: 2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N⁶-dimethylaminomethylene[1'-2H]adenosine
• CAS No.: 177978-35-7
• Molecular Formula: C₄₀H₅₀N₆O₆Si
• Molecular Weight: 739.951

Synonyms:2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N⁶-dimethylaminomethylene[1'-2H]adenosine

Chemical Property of 2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N⁶-dimethylaminomethylene[1'-2H]adenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N⁶-dimethylaminomethylene[1'-2H]adenosine

There total 9 articles about 2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N⁶-dimethylaminomethylene[1'-2H]adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

<1'-2H>adenosine (119540-53-3) → 2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N6-dimethylaminomethylene[1'-2H]adenosine (177978-35-7)

Guidance literature:

Multi-step reaction with 3 steps

2: pyridine

3: imidazole / pyridine

With pyridine; 1H-imidazole; In pyridine;

DOI:10.1135/cccc19960389

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N6-dimethylaminomethylene[1'-2H]adenosine (177978-35-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: imidazole / pyridine

With pyridine; 1H-imidazole; In pyridine;

DOI:10.1135/cccc19960389

Reference yield:

adenine (66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9) → 2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N6-dimethylaminomethylene[1'-2H]adenosine (177978-35-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 60 percent

2: SnCl₄ / acetonitrile

3: NH₄OH, MeOH / 24 h

5: pyridine

6: imidazole / pyridine

With pyridine; 1H-imidazole; methanol; ammonium hydroxide; tin(IV) chloride; In pyridine; acetonitrile;

DOI:10.1135/cccc19960389

upstream raw materials:

tert-butyldimethylsilyl chloride

C₃₄H₃₅⁽²⁾HN₆O₆

<1'-2H>adenosine

4,4'-dimethoxytrityl chloride

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