4-(1-tert-butyl-(2-methyl-1-(3'-ethynylphenylpropyl)aminooxy)ethyl)benzyl 4-azidobenzoate

Base Information

• Chemical Name: 4-(1-tert-butyl-(2-methyl-1-(3'-ethynylphenylpropyl)aminooxy)ethyl)benzyl 4-azidobenzoate
• CAS No.: 1295508-42-7
• Molecular Formula: C₃₂H₃₆N₄O₃
• Molecular Weight: 524.663
• Mol file: 1295508-42-7.mol

Synonyms:4-(1-tert-butyl-(2-methyl-1-(3'-ethynylphenylpropyl)aminooxy)ethyl)benzyl 4-azidobenzoate

Chemical Property of 4-(1-tert-butyl-(2-methyl-1-(3'-ethynylphenylpropyl)aminooxy)ethyl)benzyl 4-azidobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1-tert-butyl-(2-methyl-1-(3'-ethynylphenylpropyl)aminooxy)ethyl)benzyl 4-azidobenzoate

There total 8 articles about 4-(1-tert-butyl-(2-methyl-1-(3'-ethynylphenylpropyl)aminooxy)ethyl)benzyl 4-azidobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.6%

4-(1-tert-butyl-(2-methyl-1-(3'-(trimethylsilylethynyl)phenylpropyl)aminooxy)ethyl)benzyl 4-azidobenzoate (1239684-43-5) → 4-(1-tert-butyl-(2-methyl-1-(3'-ethynylphenylpropyl)aminooxy)ethyl)benzyl 4-azidobenzoate (1295508-42-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/pola.24126

Reference yield:

2,2,5-trimethyl-4-(3'-(trimethylsilyl)ethynyl)phenyl-3-azahexane-3-nitroxide (1239684-41-3) → 4-(1-tert-butyl-(2-methyl-1-(3'-ethynylphenylpropyl)aminooxy)ethyl)benzyl 4-azidobenzoate (1295508-42-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: (-)-chloro((1R,2R)-4,4',6,6'-tetra-tert-butyl-2,2'-[cyclohexane-1,2-diylbis(nitrilomethylidyne)]diphenolato)manganese(III); di-tert-butyl peroxide / ethanol; toluene / 0.17 h / Inert atmosphere

1.2: 18 h / Inert atmosphere

2.1: caesium carbonate / N,N,N,N,N,N-hexamethylphosphoric triamide / 48 h / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran; dichloromethane / 0.5 h / 20 °C

With (-)-chloro((1R,2R)-4,4',6,6'-tetra-tert-butyl-2,2'-[cyclohexane-1,2-diylbis(nitrilomethylidyne)]diphenolato)manganese(III); di-tert-butyl peroxide; tetrabutyl ammonium fluoride; caesium carbonate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; toluene;

DOI:10.1002/pola.24126

Reference yield:

2,2,5-trimethyl-3-(1-(4'-chloromethyl)phenylethoxy)-4-(3'-(trimethylsilyl)ethynyl)phenyl-3-azahexane (1239684-42-4) → 4-(1-tert-butyl-(2-methyl-1-(3'-ethynylphenylpropyl)aminooxy)ethyl)benzyl 4-azidobenzoate (1295508-42-7)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N,N,N,N,N-hexamethylphosphoric triamide / 48 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran; dichloromethane / 0.5 h / 20 °C

With tetrabutyl ammonium fluoride; caesium carbonate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;

DOI:10.1002/pola.24126

upstream raw materials:

4-(1-tert-butyl-(2-methyl-1-(3'-(trimethylsilylethynyl)phenylpropyl)aminooxy)ethyl)benzyl 4-azidobenzoate

2,2,5-trimethyl-4-(3'-(trimethylsilyl)ethynyl)phenyl-3-azahexane-3-nitroxide

2,2,5-trimethyl-3-(1-(4'-chloromethyl)phenylethoxy)-4-(3'-(trimethylsilyl)ethynyl)phenyl-3-azahexane

4-azidobenzoic acid

Refernces