5-Benzyloxy-2-(3-ethoxycarbonyl-propyl)-pyridine-3,4-dicarboxylic acid 3-benzyl ester 4-ethyl ester

Base Information

• Chemical Name: 5-Benzyloxy-2-(3-ethoxycarbonyl-propyl)-pyridine-3,4-dicarboxylic acid 3-benzyl ester 4-ethyl ester
• CAS No.: 101348-94-1
• Molecular Formula: C₂₉H₃₁NO₇
• Molecular Weight: 505.568
• Mol file: 101348-94-1.mol

Synonyms:5-Benzyloxy-2-(3-ethoxycarbonyl-propyl)-pyridine-3,4-dicarboxylic acid 3-benzyl ester 4-ethyl ester

Chemical Property of 5-Benzyloxy-2-(3-ethoxycarbonyl-propyl)-pyridine-3,4-dicarboxylic acid 3-benzyl ester 4-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Benzyloxy-2-(3-ethoxycarbonyl-propyl)-pyridine-3,4-dicarboxylic acid 3-benzyl ester 4-ethyl ester

There total 1 articles about 5-Benzyloxy-2-(3-ethoxycarbonyl-propyl)-pyridine-3,4-dicarboxylic acid 3-benzyl ester 4-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-benzyl-N,N'-diisopropylisourea (2978-10-1) + 2-(3-Ethoxycarbonyl-propyl)-5-hydroxy-pyridine-3,4-dicarboxylic acid 4-ethyl ester (101348-92-9) → 5-Benzyloxy-2-(3-ethoxycarbonyl-propyl)-pyridine-3,4-dicarboxylic acid 3-benzyl ester 4-ethyl ester (101348-94-1)

Guidance literature:

at 110 ℃; for 2h; Yield given;

DOI:10.1021/ja00268a040

Reference yield:

5-Benzyloxy-2-(3-ethoxycarbonyl-propyl)-pyridine-3,4-dicarboxylic acid 3-benzyl ester 4-ethyl ester (101348-94-1) → 3-Benzyloxy-5-oxo-5,6,7,8-tetrahydro-quinoline-4,6-dicarboxylic acid diethyl ester (101349-07-9)

Guidance literature:

With sodium ethanolate; In ethanol; benzene; for 0.833333h; Yield given; Heating;

DOI:10.1021/ja00268a040

Reference yield:

5-Benzyloxy-2-(3-ethoxycarbonyl-propyl)-pyridine-3,4-dicarboxylic acid 3-benzyl ester 4-ethyl ester (101348-94-1) → 3-Benzyloxy-5-(imidazole-1-carbonyloxy)-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid ethyl ester (101348-96-3)

Guidance literature:

Multi-step reaction with 4 steps

1: NaOEt / benzene; ethanol / 0.83 h / Heating

2: 41 percent / 2.4N aq. HCl / aq. ethanol / 2 h / Heating

3: 99 percent / NaBH₄, 5percent aq. NaOH / ethanol / 0.17 h / 0 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; sodium ethanolate; In ethanol; benzene;

DOI:10.1021/ja00268a040

upstream raw materials:

O-benzyl-N,N'-diisopropylisourea

2-(3-Ethoxycarbonyl-propyl)-5-hydroxy-pyridine-3,4-dicarboxylic acid 4-ethyl ester

Downstream raw materials:

3-Benzyloxy-5-oxo-5,6,7,8-tetrahydro-quinoline-4,6-dicarboxylic acid diethyl ester

3-(benzyloxy)-4-(ethoxycarbonyl)-5-oxo-5,6,7,8-tetrahydroquinoline

3-(benzyloxy)-4-(ethoxycarbonyl)-5,6,7,8-tetrahydro-5-hydroxyquinoline

(S)-3-Benzyloxy-5-hydroxy-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid ethyl ester