3-(benzyloxy)-4-(ethoxycarbonyl)-5-oxo-5,6,7,8-tetrahydroquinoline

Base Information

• Chemical Name: 3-(benzyloxy)-4-(ethoxycarbonyl)-5-oxo-5,6,7,8-tetrahydroquinoline
• CAS No.: 101348-95-2
• Molecular Formula: C₁₉H₁₉NO₄
• Molecular Weight: 325.364
• Mol file: 101348-95-2.mol

Synonyms:3-(benzyloxy)-4-(ethoxycarbonyl)-5-oxo-5,6,7,8-tetrahydroquinoline

Chemical Property of 3-(benzyloxy)-4-(ethoxycarbonyl)-5-oxo-5,6,7,8-tetrahydroquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(benzyloxy)-4-(ethoxycarbonyl)-5-oxo-5,6,7,8-tetrahydroquinoline

There total 4 articles about 3-(benzyloxy)-4-(ethoxycarbonyl)-5-oxo-5,6,7,8-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

3-Benzyloxy-5-oxo-5,6,7,8-tetrahydro-quinoline-4,6-dicarboxylic acid diethyl ester (101349-07-9) → 3-(benzyloxy)-4-(ethoxycarbonyl)-5-oxo-5,6,7,8-tetrahydroquinoline (101348-95-2)

Guidance literature:

With hydrogenchloride; In ethanol; for 2h; Heating;

DOI:10.1021/ja00268a040

Reference yield:

2-(3-Ethoxycarbonyl-propyl)-5-hydroxy-pyridine-3,4-dicarboxylic acid 4-ethyl ester (101348-92-9) → 3-(benzyloxy)-4-(ethoxycarbonyl)-5-oxo-5,6,7,8-tetrahydroquinoline (101348-95-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 2 h / 110 °C

2: NaOEt / benzene; ethanol / 0.83 h / Heating

3: 41 percent / 2.4N aq. HCl / aq. ethanol / 2 h / Heating

With hydrogenchloride; sodium ethanolate; In ethanol; benzene;

DOI:10.1021/ja00268a040

Reference yield:

2-(3-(ethoxycarbonyl)propyl)-3-(ethoxycarbonyl)-4-((benzyloxy)carbonyl)-5-(benzyloxy)pyridine (101348-93-0) → 3-(benzyloxy)-4-(ethoxycarbonyl)-5-oxo-5,6,7,8-tetrahydroquinoline (101348-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOEt / benzene / 0.83 h / Heating

2: 41 percent / 2.4N aq. HCl / aq. ethanol / 2 h / Heating

With hydrogenchloride; sodium ethanolate; In ethanol; benzene;

DOI:10.1021/ja00268a040

upstream raw materials:

3-Benzyloxy-5-oxo-5,6,7,8-tetrahydro-quinoline-4,6-dicarboxylic acid diethyl ester

2-(3-Ethoxycarbonyl-propyl)-5-hydroxy-pyridine-3,4-dicarboxylic acid 4-ethyl ester

2-(3-(ethoxycarbonyl)propyl)-3-(ethoxycarbonyl)-4-((benzyloxy)carbonyl)-5-(benzyloxy)pyridine

5-Benzyloxy-2-(3-ethoxycarbonyl-propyl)-pyridine-3,4-dicarboxylic acid 3-benzyl ester 4-ethyl ester

Downstream raw materials:

(R)-3-Benzyloxy-5-((S)-1-phenyl-ethylcarbamoyloxy)-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid ethyl ester

(S)-3-Benzyloxy-5-((S)-1-phenyl-ethylcarbamoyloxy)-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid ethyl ester

3-Benzyloxy-5-(imidazole-1-carbonyloxy)-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid ethyl ester

(S)-3-Benzyloxy-5-methanesulfonyloxy-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid ethyl ester