1-(3-chloro-2-pyrazinyl)-1-propanone

Base Information

• Chemical Name: 1-(3-chloro-2-pyrazinyl)-1-propanone
• CAS No.: 98618-78-1
• Molecular Formula: C₇H₇ClN₂O
• Molecular Weight: 170.598
• Mol file: 98618-78-1.mol

Synonyms:1-(3-chloro-2-pyrazinyl)-1-propanone

Chemical Property of 1-(3-chloro-2-pyrazinyl)-1-propanone

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

1-(3-chloro-2-pyrazinyl)-1-Propanone 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-chloro-2-pyrazinyl)-1-propanone

There total 3 articles about 1-(3-chloro-2-pyrazinyl)-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-chloro-3-(1-ethoxyprop-1-enyl)pyrazine (1371592-23-2) → 1-(3-chloro-2-pyrazinyl)-1-propanone (98618-78-1)

Guidance literature:

With hydrogenchloride; water; In 1,2-dimethoxyethane; at 60 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo300052z

Reference yield: 15.0%

2-chloropyrazin (14508-49-7) + iron(II) sulfate + propionaldehyde (123-38-6) → 1-(3-chloro-2-pyrazinyl)-1-propanone (98618-78-1)

Guidance literature:

With tert.-butylhydroperoxide; sodium sulfite; In hexane; sulfuric acid; water; acetone;

Reference yield: 15.0%

2-chloropyrazin (14508-49-7) + propionaldehyde (123-38-6) → 1-(3-chloro-2-pyrazinyl)-1-propanone (98618-78-1) + 1-(2-chloro-5-pyrazinyl)-1-propanone (118043-63-3)

Guidance literature:

With tert.-butylhydroperoxide; sulfuric acid; iron(II) sulfate; In water; at 3 - 15 ℃; for 1.5h;

DOI:10.1021/jo00264a026

upstream raw materials:

2-chloropyrazin

propionaldehyde

2-chloro-3-(1-ethoxyprop-1-enyl)pyrazine

Downstream raw materials:

1-(3-(1-benzyl-4-chloroindol-3-yl)pyrazin-2-yl)propan-1-one