N-(1-Benzyloxymethyl-propyl)-3,3,3-trifluoro-2,2-dihydroxy-propionamide

Base Information

Chemical Name:N-(1-Benzyloxymethyl-propyl)-3,3,3-trifluoro-2,2-dihydroxy-propionamide
CAS No.:206057-78-5
Molecular Formula:C₁₄H₁₈F₃NO₄
Molecular Weight:321.296
Hs Code.:

Synonyms:N-(1-Benzyloxymethyl-propyl)-3,3,3-trifluoro-2,2-dihydroxy-propionamide

Suppliers and Price of N-(1-Benzyloxymethyl-propyl)-3,3,3-trifluoro-2,2-dihydroxy-propionamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-(1-Benzyloxymethyl-propyl)-3,3,3-trifluoro-2,2-dihydroxy-propionamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(1-Benzyloxymethyl-propyl)-3,3,3-trifluoro-2,2-dihydroxy-propionamide

There total 3 articles about N-(1-Benzyloxymethyl-propyl)-3,3,3-trifluoro-2,2-dihydroxy-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 407-25-0
trifluoroacetic anhydride

: 206057-67-2
1-benzyloxy-2-isocyanobutane

: 206057-78-5
N-(1-Benzyloxymethyl-propyl)-3,3,3-trifluoro-2,2-dihydroxy-propionamide

Guidance literature:: In dichloromethane; at -50 ℃; for 4h;
DOI:10.1016/S0040-4020(98)00104-5

Reference yield:

: 100-39-0
benzyl bromide

: 206057-78-5
N-(1-Benzyloxymethyl-propyl)-3,3,3-trifluoro-2,2-dihydroxy-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) phthalic anhydride, DMAP, 2.) NaH, 3.) NH₂NH₂*H₂O / 1.) toluene, reflux, 4 h, 2.) THF, room temperature, 24 h, 3.) EtOH, reflux, 1 h

2: 2.) Et₃N, POCl₃ / 1.) room temperature, one week, 2.) CH₂Cl₂, 0 deg C, 1 h

3: 74 percent / CH₂Cl₂ / 4 h / -50 °C

With dmap; phthalic anhydride; sodium hydride; hydrazine hydrate; triethylamine; trichlorophosphate; In dichloromethane;
DOI:10.1016/S0040-4020(98)00104-5

Reference yield:

: 945757-13-1
1-benzyloxybutyl-2-amine

: 206057-78-5
N-(1-Benzyloxymethyl-propyl)-3,3,3-trifluoro-2,2-dihydroxy-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) Et₃N, POCl₃ / 1.) room temperature, one week, 2.) CH₂Cl₂, 0 deg C, 1 h

2: 74 percent / CH₂Cl₂ / 4 h / -50 °C

With triethylamine; trichlorophosphate; In dichloromethane;
DOI:10.1016/S0040-4020(98)00104-5