1,1-dimethylethyl (3R)-3-[({7-[3,4-bis(methyloxy)phenyl]pyrido[3,4-b]pyrazin-5-yl}amino)methyl]-3-fluoro-1-piperidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl (3R)-3-[({7-[3,4-bis(methyloxy)phenyl]pyrido[3,4-b]pyrazin-5-yl}amino)methyl]-3-fluoro-1-piperidinecarboxylate
CAS No.:1400589-47-0
Molecular Formula:C₂₆H₃₂FN₅O₄
Molecular Weight:497.57
Hs Code.:

Synonyms:1,1-dimethylethyl (3R)-3-[({7-[3,4-bis(methyloxy)phenyl]pyrido[3,4-b]pyrazin-5-yl}amino)methyl]-3-fluoro-1-piperidinecarboxylate

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Chemical Property of 1,1-dimethylethyl (3R)-3-[({7-[3,4-bis(methyloxy)phenyl]pyrido[3,4-b]pyrazin-5-yl}amino)methyl]-3-fluoro-1-piperidinecarboxylate

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Technology Process of 1,1-dimethylethyl (3R)-3-[({7-[3,4-bis(methyloxy)phenyl]pyrido[3,4-b]pyrazin-5-yl}amino)methyl]-3-fluoro-1-piperidinecarboxylate

There total 12 articles about 1,1-dimethylethyl (3R)-3-[({7-[3,4-bis(methyloxy)phenyl]pyrido[3,4-b]pyrazin-5-yl}amino)methyl]-3-fluoro-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400589-46-9
1,1-dimethylethyl (3R)-3-{[(7-chloropyrido[3,4-b]pyrazin-5-yl)amino]methyl}-3-fluoro-1-piperidinecarboxylate

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 1400589-47-0
1,1-dimethylethyl (3R)-3-[({7-[3,4-bis(methyloxy)phenyl]pyrido[3,4-b]pyrazin-5-yl}amino)methyl]-3-fluoro-1-piperidinecarboxylate

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 150 ℃; for 1h; Inert atmosphere; microwave irradiation; Sealed tube;

Reference yield:

: 101079-63-4
3,4-diamino-2,6-dichloropyridine

: 1400589-47-0
1,1-dimethylethyl (3R)-3-[({7-[3,4-bis(methyloxy)phenyl]pyrido[3,4-b]pyrazin-5-yl}amino)methyl]-3-fluoro-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tert-butyl alcohol / 1 h / Reflux

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 110 - 130 °C / microwave irradiation; Sealed tube

3: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 150 °C / Inert atmosphere; microwave irradiation; Sealed tube

With caesium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; tert-butyl alcohol;

Reference yield:

: 3731-16-6
3-carboethoxy-2-pyridone

: 1400589-47-0
1,1-dimethylethyl (3R)-3-[({7-[3,4-bis(methyloxy)phenyl]pyrido[3,4-b]pyrazin-5-yl}amino)methyl]-3-fluoro-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2,6-dimethylpyridine; N-fluorobenzene sulfonamide / [(S)-(-)-2,2'-bisphosphino-1,1'-binaphthyl]palladium(II) dihydrate ditriflate / ethanol / 0 - 20 °C

2.1: borane-THF / tetrahydrofuran / 24 h / Reflux

2.2: 20 °C

3.1: triethylamine / dichloromethane / 2.33 h / -10 - 0 °C

4.1: sodium azide / N,N-dimethyl-formamide / 1 h / 80 °C

5.1: hydrogen / palladium on activated charcoal / ethanol / 760.05 Torr / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 110 - 130 °C / microwave irradiation; Sealed tube

7.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 150 °C / Inert atmosphere; microwave irradiation; Sealed tube

With 2,6-dimethylpyridine; sodium azide; borane-THF; hydrogen; caesium carbonate; N-fluorobenzene sulfonamide; triethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; [(S)-(-)-2,2'-bisphosphino-1,1'-binaphthyl]palladium(II) dihydrate ditriflate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; N,N-dimethyl-formamide;