2-<2-(2,5-Dioxo-1-pyrrolidinyl)-5-methoxy-4-methylphenyl>essigsaeure

Base Information

• Chemical Name: 2-<2-(2,5-Dioxo-1-pyrrolidinyl)-5-methoxy-4-methylphenyl>essigsaeure
• CAS No.: 98911-46-7
• Molecular Formula: C₁₄H₁₅NO₅
• Molecular Weight: 277.277
• Mol file: 98911-46-7.mol

Synonyms:2-<2-(2,5-Dioxo-1-pyrrolidinyl)-5-methoxy-4-methylphenyl>essigsaeure

Chemical Property of 2-<2-(2,5-Dioxo-1-pyrrolidinyl)-5-methoxy-4-methylphenyl>essigsaeure

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<2-(2,5-Dioxo-1-pyrrolidinyl)-5-methoxy-4-methylphenyl>essigsaeure

There total 9 articles about 2-<2-(2,5-Dioxo-1-pyrrolidinyl)-5-methoxy-4-methylphenyl>essigsaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-<2-(2,5-Dioxo-1-pyrrolidinyl)-5-methoxy-4-methylphenyl>essigsaeure-tert-butylester (98911-45-6) → 2-<2-(2,5-Dioxo-1-pyrrolidinyl)-5-methoxy-4-methylphenyl>essigsaeure (98911-46-7)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 6h; Heating;

DOI:10.1002/jlac.198519850711

Reference yield:

2,5-Dimethylphenol (95-87-4) → 2-<2-(2,5-Dioxo-1-pyrrolidinyl)-5-methoxy-4-methylphenyl>essigsaeure (98911-46-7)

Guidance literature:

Multi-step reaction with 9 steps

1: sodium nitrite, conc. H₂SO₄ / acetic acid; H₂O / 0.17 h / 8 - 10 °C

2: 68percent HNO₃ / H₂O / 0.25 h / 45 °C

3: 58 percent / NaOH / H₂O / 2 h / 40 - 45 °C

4: 1) KOtBu, 2) 10percent H₂O₂, 3N NaOH / 1) benzene; 24h, reflux; 24h, r.t.

5: 76 percent / 60percent HClO₄ / 12 h / Ambient temperature

6: H₂ / 10percent Pd/C / ethyl acetate / 48 h / 735.5 Torr / Ambient temperature

7: 81 percent / dioxane; pyridine / 14 h / 5 °C

8: 96 percent / 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 15 h / Ambient temperature

9: 96 percent / p-toluenesulfonic acid / benzene / 6 h / Heating

With sodium hydroxide; perchloric acid; sulfuric acid; potassium tert-butylate; hydrogen; dihydrogen peroxide; nitric acid; benzotriazol-1-ol; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; sodium nitrite; palladium on activated charcoal; In 1,4-dioxane; pyridine; dichloromethane; water; acetic acid; ethyl acetate; benzene;

DOI:10.1002/jlac.198519850711

Reference yield:

1-methoxy-2,5-dimethyl-4-nitrobenzene (3139-06-8) → 2-<2-(2,5-Dioxo-1-pyrrolidinyl)-5-methoxy-4-methylphenyl>essigsaeure (98911-46-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 1) KOtBu, 2) 10percent H₂O₂, 3N NaOH / 1) benzene; 24h, reflux; 24h, r.t.

2: 76 percent / 60percent HClO₄ / 12 h / Ambient temperature

3: H₂ / 10percent Pd/C / ethyl acetate / 48 h / 735.5 Torr / Ambient temperature

4: 81 percent / dioxane; pyridine / 14 h / 5 °C

5: 96 percent / 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 15 h / Ambient temperature

6: 96 percent / p-toluenesulfonic acid / benzene / 6 h / Heating

With sodium hydroxide; perchloric acid; potassium tert-butylate; hydrogen; dihydrogen peroxide; benzotriazol-1-ol; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; pyridine; dichloromethane; ethyl acetate; benzene;

DOI:10.1002/jlac.198519850711

upstream raw materials:

2-<2-(2,5-Dioxo-1-pyrrolidinyl)-5-methoxy-4-methylphenyl>essigsaeure-tert-butylester

2,5-Dimethylphenol

1-methoxy-2,5-dimethyl-4-nitrobenzene

4-Nitroso-2,5-xylenol

Downstream raw materials:

(+/-)-2-Brom-2-<2-(2,5-dioxo-1-pyrrolidinyl)-5-methoxy-4-methylphenyl>essigsaeure-methylester

Refernces