1-Methoxy-2,5-diMethyl-4-nitrobenzene,

Base Information

• Chemical Name: 1-Methoxy-2,5-diMethyl-4-nitrobenzene,
• CAS No.: 3139-06-8
• Molecular Formula: C9H11 N O3
• Molecular Weight: 181.191
• Mol file: 3139-06-8.mol

Synonyms:Anisole,2,5-dimethyl-4-nitro- (7CI,8CI); 1-Methoxy-2,5-dimethyl-4-nitrobenzene;2,5-Dimethyl-4-nitroanisole; 2-Methoxy-5-nitro-1,4-dimethylbenzene; NSC 286492

Chemical Property of 1-Methoxy-2,5-diMethyl-4-nitrobenzene,

Chemical Property:

• Vapor Pressure: 0.00251mmHg at 25°C
• Melting Point: 90-92 °C
• Boiling Point: 296.6°C at 760 mmHg
• Flash Point: 136.6°C
• PSA: 55.05000
• Density: 1.148g/cm³
• LogP: 2.74340

Purity/Quality:

99%min ^*data from raw suppliers

1-Methoxy-2,5-dimethyl-4-nitrobenzene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methoxy-2,5-diMethyl-4-nitrobenzene,

There total 5 articles about 1-Methoxy-2,5-diMethyl-4-nitrobenzene, which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-nitro-2,5-xylenol (3139-05-7) + dimethyl sulfate (77-78-1) → 1-methoxy-2,5-dimethyl-4-nitrobenzene (3139-06-8)

Guidance literature:

With sodium hydroxide; In water; at 40 - 45 ℃; for 2h;

DOI:10.1002/jlac.198519850711

Reference yield: 46.0%

2,5-Dimethyl-anisol (1706-11-2) → 1-methoxy-2,5-dimethyl-4-nitrobenzene (3139-06-8)

Guidance literature:

With nitric acid; sodium nitrite; at 0 - 5 ℃; for 6.33h;

Reference yield:

2,5-Dimethylphenol (95-87-4) → 1-methoxy-2,5-dimethyl-4-nitrobenzene (3139-06-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium nitrite, conc. H₂SO₄ / acetic acid; H₂O / 0.17 h / 8 - 10 °C

2: 68percent HNO₃ / H₂O / 0.25 h / 45 °C

3: 58 percent / NaOH / H₂O / 2 h / 40 - 45 °C

With sodium hydroxide; sulfuric acid; nitric acid; sodium nitrite; In water; acetic acid;

DOI:10.1002/jlac.198519850711

upstream raw materials:

4-nitro-2,5-xylenol

dimethyl sulfate

2,5-Dimethylphenol

4-Nitroso-2,5-xylenol

Downstream raw materials:

2-(5-Methoxy-4-methyl-2-nitrophenyl)essigsaeure

ethyl N-(2,5-dimethyl-4-methoxy-3-nitrophenyl)-formimidate

2,5-dimethyl-4-methoxy-3-nitroaniline

N-<2-(tert-Butoxycarbonylmethyl)-4-methoxy-5-methylphenyl>succinamsaeure

Refernces

• 1、 -. "QUINUCLIDINES FOR MODULATING ALPHA 7 ACTIVITY". Paragraph 0379; 0380. . Retrieved 2016/02/29.
• 2、 Flitsch,Russkamp. "Studies on the synthesis of mitomycins, 1. Synthesis of the mitosane skeleton by intramolecular condensation and Reformatsky reaction". . p. 1398 - 1412. Retrieved 2007/10/02.