(1R,25)-2-(4'-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester complex with (S)-(+)-mandelic Acid

Base Information

• Chemical Name: (1R,25)-2-(4'-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester complex with (S)-(+)-mandelic Acid
• CAS No.: 1033756-47-6
• Molecular Formula: C₈H₈O₃*C₁₅H₂₀FNO₂
• Molecular Weight: 417.477
• Mol file: 1033756-47-6.mol

Synonyms:(1R,25)-2-(4'-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester complex with (S)-(+)-mandelic Acid

Chemical Property of (1R,25)-2-(4'-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester complex with (S)-(+)-mandelic Acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,25)-2-(4'-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester complex with (S)-(+)-mandelic Acid

There total 2 articles about (1R,25)-2-(4'-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester complex with (S)-(+)-mandelic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

cis-2-(4-fluoro-benzylamino)-cyclopentanecarboxylic acid ethyl ester + (S)-Mandelic acid (17199-29-0) → (1R,25)-2-(4'-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester complex with (S)-(+)-mandelic Acid (1033756-47-6)

Guidance literature:

(S)-Mandelic acid; In ethyl acetate; for 0.0166667h;

cis-2-(4-fluoro-benzylamino)-cyclopentanecarboxylic acid ethyl ester; In ethyl acetate; at 23 ℃; for 19h;

Reference yield: 40.0%

cis-2-(4'-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester + (S)-Mandelic acid (17199-29-0) → (1R,25)-2-(4'-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester complex with (S)-(+)-mandelic Acid (1033756-47-6) + C8H8O3*C15H20FNO2 (1140972-22-0)

Guidance literature:

In ethyl acetate; at 23 ℃; for 19h;

DOI:10.1016/j.tetasy.2008.11.029

Reference yield:

(1R,25)-2-(4'-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester complex with (S)-(+)-mandelic Acid (1033756-47-6) → (1R,2S)-2-(4'-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester (1033756-46-5)

Guidance literature:

With sodium hydrogencarbonate; In water; ethyl acetate; at 23 ℃;

DOI:10.1016/j.tetasy.2008.11.029

upstream raw materials:

(S)-Mandelic acid

Downstream raw materials:

ethyl (1R,2S)-2-aminocyclopentane-1-carboxylate

(1R,2S)-2-(4'-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester