Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1R-cis)- (9CI)

Base Information

• Chemical Name: Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1R-cis)- (9CI)
• CAS No.: 197916-36-2
• Molecular Formula: C8H15 N O2
• Molecular Weight: 157.213
• Mol file: 197916-36-2.mol

Synonyms:Cyclopentanecarboxylicacid, 2-amino-, ethyl ester, (1R-cis)- (9CI)

Chemical Property of Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1R-cis)- (9CI)

Chemical Property:

• Boiling Point: 213.4±33.0 °C(Predicted)
• PKA: 10.10±0.40(Predicted)
• PSA: 52.32000
• Density: 1.045±0.06 g/cm3(Predicted)
• LogP: 1.37720
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl(1R,2S)-2-aminocyclopentanecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1R-cis)- (9CI)

There total 11 articles about Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1R-cis)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

ethyl cis-2-aminocyclopentane-1-carboxylate (1609100-30-2,752181-59-2) → (1R,2S)-2-aminocyclopentanecarboxylic acid ethyl ester (197904-11-3,1609100-30-2,752181-59-2) + (1RS,2SR)-cispentacin (57043-00-2,37910-65-9) + ethyl (1R,2S)-2-aminocyclopentane-1-carboxylate (197916-36-2,1609100-30-2,752181-59-2)

Guidance literature:

With water; Candida antarctica lipase B; In di-isopropyl ether; at 65 ℃; for 87h;

DOI:10.1002/chem.200700257

Reference yield:

(1R,25)-2-(4'-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester complex with (S)-(+)-mandelic Acid (1033756-47-6) → ethyl (1R,2S)-2-aminocyclopentane-1-carboxylate (197916-36-2,1609100-30-2,752181-59-2)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In methanol; at 25 - 50 ℃; for 6h;

Reference yield:

(1R,2S)-2-tert-butoxycarbonylaminocyclopentanecarboxylic acid ethyl ester (1140972-29-7) → ethyl (1R,2S)-2-aminocyclopentane-1-carboxylate (197916-36-2,1609100-30-2,752181-59-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

upstream raw materials:

ethyl cis-2-amino-1-cyclopentane-carboxylate

ethyl cis-2-aminocyclopentane-1-carboxylate

(1R,25)-2-(4'-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester complex with (S)-(+)-mandelic Acid

(S,E)-ethyl 6-((1-(4-methoxyphenyl)ethyl)imino)hexanoate

Downstream raw materials:

(+)-(1S,2R)-2-aminocyclopentane-1-carboxylic acid hydrochloride

(1R,2S)-2-Amino-cyclopentane-1-carboxylic acid hydrochloride

trans-ethyl 2-aminocyclopentanecarboxylate