(R)-azocan-1-yl(1-(3-chloro-2-methylphenylsulfonyl)piperidin-2-yl)methanone

Base Information

Chemical Name:(R)-azocan-1-yl(1-(3-chloro-2-methylphenylsulfonyl)piperidin-2-yl)methanone
CAS No.:1472657-22-9
Molecular Formula:C₂₀H₂₉ClN₂O₃S
Molecular Weight:412.981
Hs Code.:

Synonyms:(R)-azocan-1-yl(1-(3-chloro-2-methylphenylsulfonyl)piperidin-2-yl)methanone

Suppliers and Price of (R)-azocan-1-yl(1-(3-chloro-2-methylphenylsulfonyl)piperidin-2-yl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-azocan-1-yl(1-(3-chloro-2-methylphenylsulfonyl)piperidin-2-yl)methanone

Chemical Property:

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Technology Process of (R)-azocan-1-yl(1-(3-chloro-2-methylphenylsulfonyl)piperidin-2-yl)methanone

There total 3 articles about (R)-azocan-1-yl(1-(3-chloro-2-methylphenylsulfonyl)piperidin-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80563-86-6
3-chloro-2-methylbenzenesulfonyl chloride

: 1472657-22-9
(R)-azocan-1-yl(1-(3-chloro-2-methylphenylsulfonyl)piperidin-2-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 8 h / 20 °C / Inert atmosphere

2: sodium hydroxide / water; methanol / 5 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 6 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; dichloromethane; water;
DOI:10.1002/cmdc.201300022

Reference yield:

: 1121-92-2
heptamethyleneimine

: 1472657-63-8
C₁₃H₁₆ClNO₄S

: 1472657-22-9
(R)-azocan-1-yl(1-(3-chloro-2-methylphenylsulfonyl)piperidin-2-yl)methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1002/cmdc.201300022

Reference yield:

: 1472657-62-7
(R)-methyl 1-(3-chloro-2-methylphenylsulfonyl)-N-cyclohexylpiperidine-2-carboxylate

: 1472657-22-9
(R)-azocan-1-yl(1-(3-chloro-2-methylphenylsulfonyl)piperidin-2-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; methanol / 5 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 6 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; dichloromethane; water;
DOI:10.1002/cmdc.201300022