Technology Process of (3R,4S,3'S,4'R)-3-Amino-1'-((S)-1-benzyloxymethyl-3-methyl-butyl)-4,4'-diphenyl-[1,3']biazetidinyl-2,2'-dione
There total 9 articles about (3R,4S,3'S,4'R)-3-Amino-1'-((S)-1-benzyloxymethyl-3-methyl-butyl)-4,4'-diphenyl-[1,3']biazetidinyl-2,2'-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
at 0 - 5 ℃;
DOI:10.1021/ja00240a033
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) potassium hydride / 1.) THF, RT, 17.5 h; 2.) THF, RT, 3 h
2: 92 percent / sodium sulfate / benzene / Ambient temperature
3: triethylamine / CH2Cl2 / -78 deg C to room temperature
4: H2 / 5 percent Pd-C / methanol / 6 h / 0 - 5 °C
5: sodium sulfate / benzene / Ambient temperature
6: 60 percent / triethylamine / CH2Cl2 / -78 deg C to room temperature
7: H2 / 5 percent Pd-C / methanol / 0 - 5 °C
With
hydrogen; potassium hydride; sodium sulfate; triethylamine;
palladium on activated charcoal;
In
methanol; dichloromethane; benzene;
DOI:10.1021/ja00240a033
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) potassium hydride / 1.) THF, RT, 17.5 h; 2.) THF, RT, 3 h
2: 92 percent / sodium sulfate / benzene / Ambient temperature
3: triethylamine / CH2Cl2 / -78 deg C to room temperature
4: H2 / 5 percent Pd-C / methanol / 6 h / 0 - 5 °C
5: sodium sulfate / benzene / Ambient temperature
6: 60 percent / triethylamine / CH2Cl2 / -78 deg C to room temperature
7: H2 / 5 percent Pd-C / methanol / 0 - 5 °C
With
hydrogen; potassium hydride; sodium sulfate; triethylamine;
palladium on activated charcoal;
In
methanol; dichloromethane; benzene;
DOI:10.1021/ja00240a033
