(4aR,6S,8aS)-2-(benzoylamino)-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-6-yl acetate

Base Information

Chemical Name:(4aR,6S,8aS)-2-(benzoylamino)-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-6-yl acetate
CAS No.:1621585-54-3
Molecular Formula:C₂₂H₂₀F₂N₂O₄S
Molecular Weight:446.475
Hs Code.:

Synonyms:(4aR,6S,8aS)-2-(benzoylamino)-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-6-yl acetate

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Chemical Property of (4aR,6S,8aS)-2-(benzoylamino)-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-6-yl acetate

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Technology Process of (4aR,6S,8aS)-2-(benzoylamino)-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-6-yl acetate

There total 10 articles about (4aR,6S,8aS)-2-(benzoylamino)-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-6-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: (4aR,6R,8aS)-2-(benzoylamino)-8a-(2,4-difluorophenyl)-4,4-a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazine-6-carboxylic acid

: 546-67-8
lead(IV) tetraacetate

: 1621585-54-3
(4aR,6S,8aS)-2-(benzoylamino)-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-6-yl acetate

Guidance literature:: In tetrahydrofuran; acetic acid; at 20 ℃; for 18h;

Reference yield:

: N-[(4aR,6R,8aS)-6-[(benzyloxy)methyl]-8a-(2,4-difluorophenyl)-20 4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide

: 1621585-54-3
(4aR,6S,8aS)-2-(benzoylamino)-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-6-yl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: boron trichloride / dichloromethane; n-heptane / 4.25 h / 0 - 20 °C

2: tetrapropylammonium permanganate; 4-methylmorpholine N-oxide / acetonitrile / 1.5 h / 20 °C

3: tetrahydrofuran; acetic acid / 18 h / 20 °C

With tetrapropylammonium permanganate; boron trichloride; 4-methylmorpholine N-oxide; In tetrahydrofuran; n-heptane; dichloromethane; acetic acid; acetonitrile;

Reference yield:

: N-[(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(hydroxymethyl)-4,4-a,5,6,8,8a-hexahydropyrano[3,4-c][1,3]thiazin-2-yl]benzamide

: 1621585-54-3
(4aR,6S,8aS)-2-(benzoylamino)-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-6-yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrapropylammonium permanganate; 4-methylmorpholine N-oxide / acetonitrile / 1.5 h / 20 °C

2: tetrahydrofuran; acetic acid / 18 h / 20 °C

With tetrapropylammonium permanganate; 4-methylmorpholine N-oxide; In tetrahydrofuran; acetic acid; acetonitrile;