(3aR,5R,7aS)-5-[(benzyloxy)methyl]-7a-(2,4-difluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole

Base Information

Chemical Name:(3aR,5R,7aS)-5-[(benzyloxy)methyl]-7a-(2,4-difluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole
CAS No.:1425947-61-0
Molecular Formula:C₂₀H₂₁F₂NO₃
Molecular Weight:361.388
Hs Code.:

Synonyms:(3aR,5R,7aS)-5-[(benzyloxy)methyl]-7a-(2,4-difluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole

Suppliers and Price of (3aR,5R,7aS)-5-[(benzyloxy)methyl]-7a-(2,4-difluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3aR,5R,7aS)-5-[(benzyloxy)methyl]-7a-(2,4-difluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3aR,5R,7aS)-5-[(benzyloxy)methyl]-7a-(2,4-difluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole

There total 6 articles about (3aR,5R,7aS)-5-[(benzyloxy)methyl]-7a-(2,4-difluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1220328-97-1
(3aR,5R)-5-[(benzyloxy)methyl]-3,3a,4,5-tetrahydro-7H-pyrano[3,4-c][1,2]oxazole

: 2265-93-2
2,4-difluoro-1-iodobenzene

: 1425947-61-0
(3aR,5R,7aS)-5-[(benzyloxy)methyl]-7a-(2,4-difluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole

Guidance literature:: (3aR,5R)-5-[(benzyloxy)methyl]-3,3a,4,5-tetrahydro-7H-pyrano[3,4-c][1,2]oxazole; With boron trifluoride diethyl etherate; In di-isopropyl ether; toluene; at -76 ℃; for 0.5h;

2,4-difluoro-1-iodobenzene; With n-butyllithium; In di-isopropyl ether; toluene; at -76 - -71 ℃; for 1.5h;

Reference yield:

: 1220328-95-9
2-{[(2R)-1-(benzyloxy)pent-4-en-2-yl]oxy}-N-hydroxyethanimine

: 1425947-61-0
(3aR,5R,7aS)-5-[(benzyloxy)methyl]-7a-(2,4-difluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hypochlorite; triethylamine / water; dichloromethane / 22 - 25.5 °C

2.1: boron trifluoride diethyl etherate / toluene; di-isopropyl ether / 0.5 h / -78 °C

2.2: 1 h / -78 - -73 °C

With sodium hypochlorite; boron trifluoride diethyl etherate; triethylamine; In dichloromethane; di-isopropyl ether; water; toluene;

Reference yield:

: 14618-80-5
(R)-benzyl glycidol

: 1425947-61-0
(3aR,5R,7aS)-5-[(benzyloxy)methyl]-7a-(2,4-difluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(l) iodide / diethyl ether; tetrahydrofuran / 18 h / -78 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 42 h / 0 °C / Reflux

3.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 75 °C

4.1: sodium acetate; hydroxylamine hydrochloride / ethanol; water / 18 h / 60 °C

5.1: sodium hypochlorite; triethylamine / water; dichloromethane / 22 - 25.5 °C

6.1: boron trifluoride diethyl etherate / toluene; di-isopropyl ether / 0.5 h / -78 °C

6.2: 1 h / -78 - -73 °C

With hydrogenchloride; sodium hypochlorite; copper(l) iodide; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; water; sodium acetate; sodium hydride; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; di-isopropyl ether; water; toluene; mineral oil;