N₁-((R)-1-(4-chlorophenyl)ethyl)-6-methyl-N₅-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine

Base Information

• Chemical Name: N₁-((R)-1-(4-chlorophenyl)ethyl)-6-methyl-N₅-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine
• CAS No.: 1093101-70-2
• Molecular Formula: C₃₃H₃₁ClN₈O
• Molecular Weight: 591.115

Synonyms:N₁-((R)-1-(4-chlorophenyl)ethyl)-6-methyl-N₅-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine

Chemical Property of N₁-((R)-1-(4-chlorophenyl)ethyl)-6-methyl-N₅-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine

Chemical Property:

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Technology Process of N₁-((R)-1-(4-chlorophenyl)ethyl)-6-methyl-N₅-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine

There total 10 articles about N₁-((R)-1-(4-chlorophenyl)ethyl)-6-methyl-N₅-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-N1-(1-(4-chlorophenyl)ethyl)-6-methylisoquinoline-1,5-diamine (1093101-69-9) + 6-(2-fluoropyridin-3-yl)-9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purine (1093101-52-0) → N1-((R)-1-(4-chlorophenyl)ethyl)-6-methyl-N5-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine (1093101-70-2)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 2h;

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → N1-((R)-1-(4-chlorophenyl)ethyl)-6-methyl-N5-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine (1093101-70-2)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / ethyl acetate / 1 h / 90 °C

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 10 h / 100 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 °C

With sodium carbonate; toluene-4-sulfonic acid; lithium hexamethyldisilazane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; 2: Suzuki Coupling;

Reference yield:

6-chloropurine (87-42-3) → N1-((R)-1-(4-chlorophenyl)ethyl)-6-methyl-N5-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine (1093101-70-2)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / ethyl acetate / 1 h / 90 °C

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 10 h / 100 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 °C

With sodium carbonate; toluene-4-sulfonic acid; lithium hexamethyldisilazane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; 2: Suzuki Coupling;

upstream raw materials:

(R)-N₁-(1-(4-chlorophenyl)ethyl)-6-methylisoquinoline-1,5-diamine

6-(2-fluoropyridin-3-yl)-9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purine

6-methyl-5-nitroisoquinoline

3,4-dihydro-2H-pyran

Downstream raw materials:

N₅-(3-(9H-purin-6-yl)pyridin-2-yl)-N₁-((R)-1-(4-chlorophenyl)ethyl)-6-methylisoquinoline-1,5-diamine

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