2-(1-(2-(2,4-dichlorophenyl)-2-(4-(trifluoromethoxy)benzyloxy)ethyl)-1H-1,2,3-triazol-4-yl)ethanol

Base Information

Chemical Name:2-(1-(2-(2,4-dichlorophenyl)-2-(4-(trifluoromethoxy)benzyloxy)ethyl)-1H-1,2,3-triazol-4-yl)ethanol
CAS No.:1301628-97-6
Molecular Formula:C₂₀H₁₈Cl₂F₃N₃O₃
Molecular Weight:476.282
Hs Code.:

Synonyms:2-(1-(2-(2,4-dichlorophenyl)-2-(4-(trifluoromethoxy)benzyloxy)ethyl)-1H-1,2,3-triazol-4-yl)ethanol

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Chemical Property of 2-(1-(2-(2,4-dichlorophenyl)-2-(4-(trifluoromethoxy)benzyloxy)ethyl)-1H-1,2,3-triazol-4-yl)ethanol

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Technology Process of 2-(1-(2-(2,4-dichlorophenyl)-2-(4-(trifluoromethoxy)benzyloxy)ethyl)-1H-1,2,3-triazol-4-yl)ethanol

There total 3 articles about 2-(1-(2-(2,4-dichlorophenyl)-2-(4-(trifluoromethoxy)benzyloxy)ethyl)-1H-1,2,3-triazol-4-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1301629-39-9
1-(2-azido-1-(4-(trifluoromethoxy)benzyloxy)ethyl)-2,4-dichlorobenzene

: 927-74-2
3-Butyn-1-ol

: 1301628-97-6
2-(1-(2-(2,4-dichlorophenyl)-2-(4-(trifluoromethoxy)benzyloxy)ethyl)-1H-1,2,3-triazol-4-yl)ethanol

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 150 ℃; for 0.166667h; Microwave irradiation;
DOI:10.1016/j.bmcl.2012.09.041

Reference yield:

: 13692-14-3,114446-57-0
α-(chloromethyl)-2,4-dichlorobenzyl alcohol

: 1301628-97-6
2-(1-(2-(2,4-dichlorophenyl)-2-(4-(trifluoromethoxy)benzyloxy)ethyl)-1H-1,2,3-triazol-4-yl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 12 h / Reflux

2: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide; mineral oil / -78 - 20 °C / Inert atmosphere

3: copper(l) iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 150 °C / Microwave irradiation

With copper(l) iodide; sodium azide; tetra-(n-butyl)ammonium iodide; sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2012.09.041

Reference yield:

: 1301629-37-7
2-azido-1-(2,4-dichlorophenyl)ethan-1-ol

: 1301628-97-6
2-(1-(2-(2,4-dichlorophenyl)-2-(4-(trifluoromethoxy)benzyloxy)ethyl)-1H-1,2,3-triazol-4-yl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide; mineral oil / -78 - 20 °C / Inert atmosphere

2: copper(l) iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 150 °C / Microwave irradiation

With copper(l) iodide; tetra-(n-butyl)ammonium iodide; sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2012.09.041