(S)-2-amino-4-[4-(5-trifluoromethyl-pyridin-2-ylamino)-phenyl]-butan-1-ol

Base Information

Chemical Name:(S)-2-amino-4-[4-(5-trifluoromethyl-pyridin-2-ylamino)-phenyl]-butan-1-ol
CAS No.:1374037-60-1
Molecular Formula:C₁₆H₁₈F₃N₃O
Molecular Weight:325.334
Hs Code.:

Synonyms:(S)-2-amino-4-[4-(5-trifluoromethyl-pyridin-2-ylamino)-phenyl]-butan-1-ol

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Chemical Property of (S)-2-amino-4-[4-(5-trifluoromethyl-pyridin-2-ylamino)-phenyl]-butan-1-ol

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Technology Process of (S)-2-amino-4-[4-(5-trifluoromethyl-pyridin-2-ylamino)-phenyl]-butan-1-ol

There total 4 articles about (S)-2-amino-4-[4-(5-trifluoromethyl-pyridin-2-ylamino)-phenyl]-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1374037-59-8
(S)-2,2-dimethyl-4-{2-[4-(5-trifluoromethyl-pyridin-2-ylamino)-phenyl]-ethyl}-oxazolidine-3-carboxylic acid tert-butyl ester

: 1374037-60-1
(S)-2-amino-4-[4-(5-trifluoromethyl-pyridin-2-ylamino)-phenyl]-butan-1-ol

Guidance literature:: (S)-2,2-dimethyl-4-{2-[4-(5-trifluoromethyl-pyridin-2-ylamino)-phenyl]-ethyl}-oxazolidine-3-carboxylic acid tert-butyl ester; With water; trifluoroacetic acid; In acetonitrile; at 80 ℃; for 2h;

With sodium hydroxide; In water; ethyl acetate; acetonitrile; at 20 ℃;

Reference yield:

: 2609-49-6
diethyl p-nitrobenzylphosphonate

: 1374037-60-1
(S)-2-amino-4-[4-(5-trifluoromethyl-pyridin-2-ylamino)-phenyl]-butan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 20 °C

2.1: ammonium formate / palladium 10% on activated carbon / methanol / 1 h / 50 °C

3.1: potassium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 1 h / 110 °C / Inert atmosphere; Sealed tube

4.1: trifluoroacetic acid; water / acetonitrile / 2 h / 80 °C

4.2: 20 °C

With n-butyllithium; water; ammonium formate; potassium carbonate; diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; hexane; toluene; acetonitrile; 1.2: Wittig Reaction / 3.1: Buchwald-Hartwig Reaction;

Reference yield:

: 1302579-22-1
(S)-2,2-dimethyl-4-[(E)-2-(4-nitrophenyl)vinyl]oxazolidine-3-carboxylic acid tert-butyl ester

: 1374037-60-1
(S)-2-amino-4-[4-(5-trifluoromethyl-pyridin-2-ylamino)-phenyl]-butan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium formate / palladium 10% on activated carbon / methanol / 1 h / 50 °C

2.1: potassium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 1 h / 110 °C / Inert atmosphere; Sealed tube

3.1: trifluoroacetic acid; water / acetonitrile / 2 h / 80 °C

3.2: 20 °C

With water; ammonium formate; potassium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In methanol; toluene; acetonitrile; 2.1: Buchwald-Hartwig Reaction;