(1R,3S)-3-(4-(3-(4-((S)-tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)phenylamino)cyclopentanecarboxylic acid

Base Information

Chemical Name:(1R,3S)-3-(4-(3-(4-((S)-tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)phenylamino)cyclopentanecarboxylic acid
CAS No.:1311232-12-8
Molecular Formula:C₂₅H₂₄F₃N₃O₅
Molecular Weight:503.478
Hs Code.:

Synonyms:(1R,3S)-3-(4-(3-(4-((S)-tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)phenylamino)cyclopentanecarboxylic acid

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Chemical Property of (1R,3S)-3-(4-(3-(4-((S)-tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)phenylamino)cyclopentanecarboxylic acid

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Technology Process of (1R,3S)-3-(4-(3-(4-((S)-tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)phenylamino)cyclopentanecarboxylic acid

There total 2 articles about (1R,3S)-3-(4-(3-(4-((S)-tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)phenylamino)cyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.33%

: 1311255-51-2
(S)-5-(4-fluorophenyl)-3-(4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

: 71830-08-5
(1R,3S)-3-aminocyclopentanecarboxylic acid

: 1311232-12-8
(1R,3S)-3-(4-(3-(4-((S)-tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)phenylamino)cyclopentanecarboxylic acid

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 160 ℃; for 0.5h; microwave irradiation;

Reference yield:

: 1311255-50-1,1312023-75-8
(S,Z)-N'-hydroxy-4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)benzimidamide

: 403-43-0
4-fluorobenzoyl chloride

: 1311232-12-8
(1R,3S)-3-(4-(3-(4-((S)-tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)phenylamino)cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 0.42 h / 160 °C / microwave irradiation; sealed tube

2: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 160 °C / microwave irradiation

With pyridine; potassium carbonate; In N,N-dimethyl-formamide;