N-(2-methylquinolin-8-yl)benzenesulfonamide

Base Information

• Chemical Name: N-(2-methylquinolin-8-yl)benzenesulfonamide
• CAS No.: 15011-26-4
• Molecular Formula: C₁₆H₁₄N₂O₂S
• Molecular Weight: 298.365
• Mol file: 15011-26-4.mol

Synonyms:2-((4-((7-chloro-2-methylquinolin-4-yl)amino)pentyl)(ethyl)amino)ethan-1-ol

Chemical Property of N-(2-methylquinolin-8-yl)benzenesulfonamide

Chemical Property:

• Vapor Pressure: 1.29E-09mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-methylquinolin-8-yl)benzenesulfonamide

There total 3 articles about N-(2-methylquinolin-8-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-methyl-8-aminoquinoline (18978-78-4) + benzenesulfonyl chloride (98-09-9) → 2-((4-((7-chloro-2-methylquinolin-4-yl)amino)pentyl)(ethyl)amino)ethan-1-ol (15011-26-4)

Guidance literature:

With pyridine; at 0 - 5 ℃; for 3h;

DOI:10.1016/S0040-4020(02)00451-9

Reference yield: 43.0%

→ 2-((4-((7-chloro-2-methylquinolin-4-yl)amino)pentyl)(ethyl)amino)ethan-1-ol (15011-26-4)

Guidance literature:

Reference yield:

8-nitroquinaldine (881-07-2) → 2-((4-((7-chloro-2-methylquinolin-4-yl)amino)pentyl)(ethyl)amino)ethan-1-ol (15011-26-4)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / 1,4-dioxane / 12 h

2: pyridine / 3 h / Cooling with ice

With pyridine; palladium 10% on activated carbon; hydrogen; In 1,4-dioxane;

DOI:10.5012/bkcs.2010.31.11.3391

upstream raw materials:

2-methyl-8-aminoquinoline

benzenesulfonyl chloride

8-nitroquinaldine

Downstream raw materials:

5-(4-nitrobenzenediazo)-8-benzenesulfonamidoquinaldine

8-benzenesulfonamido-2-quinolinecarboxaldehyde

Refernces

• 1、 -. "Novel Sulfonaminoquinoline Hepcidin Antagonists". Page/Page column 136. . Retrieved 2012/09/05.
• 2、 Lee, Jeong Won,Jung, Hyo Sung,Kwon, Pil Seung,Kim, Jong Wan,Bartsch, Richard A.,Kim, Youngmee,Kim, Sung-Jin,Kim, Jong Seung. "Chromofluorescent indicator for intracellular Zn2+/Hg 2+ dynamic exchange". supporting information; scheme or table. p. 3801 - 3804. Retrieved 2009/07/01.