2-(4-methoxy-3-phenylmethoxyphenyl)-N-[2-(3-methoxy-4-phenylmethoxyphenyl)ethyl]acetamide

Base Information

Chemical Name:2-(4-methoxy-3-phenylmethoxyphenyl)-N-[2-(3-methoxy-4-phenylmethoxyphenyl)ethyl]acetamide
CAS No.:1699-40-7
Molecular Formula:C₃₂H₃₃NO₅
Molecular Weight:511.618
Hs Code.:
European Community (EC) Number:683-456-9
DSSTox Substance ID:DTXSID701121814

Synonyms:1699-40-7;2-(4-methoxy-3-phenylmethoxyphenyl)-N-[2-(3-methoxy-4-phenylmethoxyphenyl)ethyl]acetamide;N-[4-(Benzyloxy)-3-Methoxyphenethyl]-2-[3-(benzyloxy)-4-Methoxyphenyl]acetaMide;Oprea1_325584;SCHEMBL14027267;KLWHDTDRLRBMKJ-UHFFFAOYSA-N;DTXSID701121814;AKOS004907085;2-[3-(benzyloxy)-4-methoxyphenyl]-N-{2-[4-(benzyloxy)-3-methoxyphenyl]ethyl}acetamide;4-Methoxy-N-[2-[3-methoxy-4-(phenylmethoxy)phenyl]ethyl]-3-(phenylmethoxy)benzeneacetamide

Suppliers and Price of 2-(4-methoxy-3-phenylmethoxyphenyl)-N-[2-(3-methoxy-4-phenylmethoxyphenyl)ethyl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-methoxy-3-phenylmethoxyphenyl)-N-[2-(3-methoxy-4-phenylmethoxyphenyl)ethyl]acetamide

Chemical Property:

XLogP3:6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:13
Exact Mass:511.23587315
Heavy Atom Count:38
Complexity:662

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)CC(=O)NCCC2=CC(=C(C=C2)OCC3=CC=CC=C3)OC)OCC4=CC=CC=C4

Technology Process of 2-(4-methoxy-3-phenylmethoxyphenyl)-N-[2-(3-methoxy-4-phenylmethoxyphenyl)ethyl]acetamide

There total 15 articles about 2-(4-methoxy-3-phenylmethoxyphenyl)-N-[2-(3-methoxy-4-phenylmethoxyphenyl)ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5487-33-2
O-benzylhomoisovanillic acid

: 1699-40-7
(3-benzyloxy-4-methoxy-phenyl)-acetic acid-(4-benzyloxy-3-methoxy-phenethylamide)

Guidance literature:: With phosphorus pentachloride; Behandeln des hergestellten Saeurechlorids mit 4-Benzyloxy-3-methoxy-phenaethylamin in Benzol unter Zusatz von wss.NaOH;

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 1699-40-7
(3-benzyloxy-4-methoxy-phenyl)-acetic acid-(4-benzyloxy-3-methoxy-phenethylamide)

Guidance literature:: Multi-step reaction with 6 steps

1: NaOAc / acetic acid

2: aq. NaOH

3: aq. NH₂OH*HCl, NaOEt

4: Ac₂O

5: LiAlH₄

6: 180 °C

With sodium hydroxide; lithium aluminium tetrahydride; hydroxylamine hydrochloride; sodium ethanolate; sodium acetate; acetic anhydride; In acetic acid;
DOI:10.1039/jr9650003645

Reference yield:

: 100-39-0
benzyl bromide

: 1699-40-7
(3-benzyloxy-4-methoxy-phenyl)-acetic acid-(4-benzyloxy-3-methoxy-phenethylamide)

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 6 h / Heating

2: acetic acid; ethylenediamine / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 20 °C

4: sodium carbonate / dichloromethane; water / 2 h / 20 °C

With lithium aluminium tetrahydride; sodium carbonate; potassium carbonate; acetic acid; ethylenediamine; In tetrahydrofuran; dichloromethane; water; acetone; 2: Knoevenagel reaction;
DOI:10.1021/jo061810h