(S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid adamantan-1-ylmethyl ester

Base Information

Chemical Name:(S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid adamantan-1-ylmethyl ester
CAS No.:139143-47-8
Molecular Formula:C₂₅H₃₅NO₄
Molecular Weight:413.557
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid adamantan-1-ylmethyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid adamantan-1-ylmethyl ester

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Technology Process of (S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid adamantan-1-ylmethyl ester

There total 1 articles about (S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid adamantan-1-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 2018-66-8
Z-Leu-OH

: 770-71-8
1-adamantanemethanol

: 139143-47-8
(S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid adamantan-1-ylmethyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 4 ℃; for 24h;
DOI:10.1248/cpb.45.1782

Reference yield:

: 139143-47-8
(S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid adamantan-1-ylmethyl ester

: (S)-2-((S)-2-Amino-3-phenyl-propionylamino)-4-methyl-pentanoic acid adamantan-1-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂, AcOH / 5percent Pd/C / tetrahydrofuran / 5 h

2: Et₃N / dimethylformamide / 48 h / 15 °C

3: H₂, AcOH / 5percent Pd/C / tetrahydrofuran / 5 h

With hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1782

Reference yield:

: 139143-47-8
(S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid adamantan-1-ylmethyl ester

: 139143-49-0
(S)-2-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoic acid adamantan-1-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂, AcOH / 5percent Pd/C / tetrahydrofuran / 5 h

2: Et₃N / dimethylformamide / 48 h / 15 °C

With hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1782