t-butyl 1-(((2R)-2-(4-(2-methylpentyloxy)phenyl)-2-((S)-2-phenylpropanamido)ethylamino)methyl)-cyclopentylcarbamate

Base Information

Chemical Name:t-butyl 1-(((2R)-2-(4-(2-methylpentyloxy)phenyl)-2-((S)-2-phenylpropanamido)ethylamino)methyl)-cyclopentylcarbamate
CAS No.:1287286-29-6
Molecular Formula:C₃₄H₅₁N₃O₄
Molecular Weight:565.797
Hs Code.:

Synonyms:t-butyl 1-(((2R)-2-(4-(2-methylpentyloxy)phenyl)-2-((S)-2-phenylpropanamido)ethylamino)methyl)-cyclopentylcarbamate

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Chemical Property of t-butyl 1-(((2R)-2-(4-(2-methylpentyloxy)phenyl)-2-((S)-2-phenylpropanamido)ethylamino)methyl)-cyclopentylcarbamate

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Technology Process of t-butyl 1-(((2R)-2-(4-(2-methylpentyloxy)phenyl)-2-((S)-2-phenylpropanamido)ethylamino)methyl)-cyclopentylcarbamate

There total 10 articles about t-butyl 1-(((2R)-2-(4-(2-methylpentyloxy)phenyl)-2-((S)-2-phenylpropanamido)ethylamino)methyl)-cyclopentylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 168539-99-9
tert-butyl (1-formylcyclopentyl)carbamate

: 1287285-96-4
(2S)-N-{(1R)-2-amino-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide

: 1287286-29-6
t-butyl 1-(((2R)-2-(4-(2-methylpentyloxy)phenyl)-2-((S)-2-phenylpropanamido)ethylamino)methyl)-cyclopentylcarbamate

Guidance literature:: tert-butyl (1-formylcyclopentyl)carbamate; (2S)-N-{(1R)-2-amino-1-[4-(2-methylpentyloxy)phenyl]ethyl}-2-phenylpropanamide; In acetonitrile; for 0.25h;

With sodium tris(acetoxy)borohydride; In acetonitrile; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In water; acetonitrile;

Reference yield:

: 57591-61-4,68697-60-9,127369-30-6,134694-94-3
methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride

: 1287286-29-6
t-butyl 1-(((2R)-2-(4-(2-methylpentyloxy)phenyl)-2-((S)-2-phenylpropanamido)ethylamino)methyl)-cyclopentylcarbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: triphenylphosphine / tetrahydrofuran / 0.17 h

2.2: 18 h / 20 °C

3.1: lithium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 0 - 20 °C

3.2: 0 °C

4.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 1 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

8.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 2068.65 Torr

9.1: acetonitrile / 0.25 h

9.2: 1 h / 20 °C

With sodium tetrahydroborate; sodium azide; carbon tetrabromide; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; lithium chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 7782-24-3
(S)-2-Phenylpropionic acid

: 1287286-29-6
t-butyl 1-(((2R)-2-(4-(2-methylpentyloxy)phenyl)-2-((S)-2-phenylpropanamido)ethylamino)methyl)-cyclopentylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 2068.65 Torr

3.1: acetonitrile / 0.25 h

3.2: 1 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In ethanol; dichloromethane; acetonitrile;